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High cholesterol intake leads to reduced cholesterol synthesis and increased bile acid synthesis

High cholesterol intake leads to reduced cholesterol synthesis and increased bile acid synthesis Both of these changes represent changes in expression of rate limiting enzymes eg. HMG CoA reductase (down) Cyp7a1 (up) In addition, bile acids also regulate gene expression,

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Trans repression - PowerPoint PPT Presentation

High cholesterol intake leads to reduced cholesterol synthesis and increased bile acid synthesis