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Epistasis and a Flexible Framework for Detecting Epistasis

Jason H Moore: A global view of epistasis. Nature Genetics 37, 13-14 (2005).Jason H Moore et al.: A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility. Journal of Theoretical Biology

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Epistasis and a Flexible Framework for Detecting Epistasis

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    1. Epistasis and a Flexible Framework for Detecting Epistasis Yixuan Chen 11/9/2007

    2. Jason H Moore: A global view of epistasis. Nature Genetics 37, 13-14 (2005). Jason H Moore et al.: A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility. Journal of Theoretical Biology 241, 252-261 (2006).

    3. Outline Epistasis The flexible framework Experiment Design Results Discussions In the Future

    4. Epistasis Epistasis is a phenomenon whereby the effects of a given gene on a biological trait are masked or enhanced by one or more other genes. For complex traits such as diabetes, asthma, hypertension, etc., the presence of epistasis is a particular cause for concern.

    5. Biological and Statistical Epistasis The physical interactions among proteins and other biomolecules and their impact on phenotype constitute biological epistasis. Deviations from additivity in a linear statistical model define statistical epistasis. The relationship between biological and statistical epistasis is important and needs further research efforts.

    6. Why is There Epistasis? From an evolutionary biology perspective, for a phenotype to be buffered against the effects of mutations, it must have an underlying genetic architecture that is comprised of networks of genes that are redundant and robust. This creates dependencies among the genes in the network and is realized as epistasis.

    7. A Simple Example

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