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Medical complication of preg. Diabetes in Pregnancy. Incidence – affects 1 in 300 pregnancies Maybe gestational or overt diabetes Increases the risks of perinatal mortality up to 40% Risks are greater with poor diabetic control
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Medical complication of preg Mrs.Mahdia Samaha Kony
Diabetes in Pregnancy • Incidence – affects 1 in 300 pregnancies • Maybe gestational or overt diabetes • Increases the risks of perinatal mortality up to 40% • Risks are greater with poor diabetic control • With good diabetic management the mortality rates decrease significantly Mrs.Mahdia Samaha Kony
health history • Large birth weight babies (over 9 lbs.) • Unexplained fetal losses • Infants with anomalies • Family history of DM • Previous gestational diabetes (GDM) Mrs.Mahdia Samaha Kony
Diagnostic Tests • Glucosuria – on 2 successive visits • Blood sugar levels • FBS of ^^ 140 • Random of ^^ 200 • Glucose Tolerance tests • At 24-28 weeks 1 hour screen ^^ 140 • 3-hour GTT with 2 elevated levels = GDM Mrs.Mahdia Samaha Kony
Effects on the Pregnancy • Early (up to 18 weeks) glucose levels may decrease • Mother at risk for hypoglycemia • After 20 weeks • Placental hormones cause ^^ resistance to insulin utilization • Hyperglycemia • Ketoacidosis Mrs.Mahdia Samaha Kony
Other maternal risks • Infections – pyelonephritis • Pregnancy induced hypertension • Polyhydramnios • DIC Mrs.Mahdia Samaha Kony
Effects on the Unborn baby • Related to diabetic control • With chronic hyperglycemia, vascular changes which lead to placental insufficiency • First trimester = spontaneous abortion or fetal anomalies • Third trimester = Intrauterine fetal demise (Greatest risks after 36 weeks) Mrs.Mahdia Samaha Kony
Effects on the Newborn • Large birth weights • Often large, immature pre-term babies • Neonatal hypoglycemia • Hyperbilirubinemia Mrs.Mahdia Samaha Kony
Treatment and Nursing care • Frequent hospitalizations • Urine test for ketones • Frequent blood glucose levels • Insulin management • Diet Mrs.Mahdia Samaha Kony
Fetal Evaluations • Ultrasound for size, growth • Daily kick counts • Non-stress tests • OCT • 24 hour urine for estriol levels • L/S ratio for surfactant levels Mrs.Mahdia Samaha Kony
Delivery plans • Careful monitoring • Plan for delivery between 36 – 40 weeks • Goal is two-fold: • To proceed as close to term as possible • Monitor fetal condition to avoid fetal demise Mrs.Mahdia Samaha Kony
Follow-up information • With Gestational Diabetes: • 7% may become overt Diabetic within 6 months • 28 – 40 % may become Diabetic with 5 to 5 ½ years Mrs.Mahdia Samaha Kony
Rh Incompatibility • Antigen – antibody reaction • Mother is Rh negative • Usually no problem with first pregnancy • With subsequent pregnancies maternal antibodies destroy fetal RBCs Mrs.Mahdia Samaha Kony
Symptoms • Low muscle tone (hypotonia) • Developmental delay • Polyhydramnios • Jaundice Mrs.Mahdia Samaha Kony
Laboratory tests • A positive direct Coombs test result. • Higher levels of bilirubin in the baby's cord blood • Signs of red blood cell destruction in the infant's blood Mrs.Mahdia Samaha Kony
Possible Complications • Hydrops fetalis (potentially deadly fluid buildup and swelling in the baby) • Kernicterus (brain damage due to high levels of bilirubin) • Neurological syndrome with mental deficiency, movement disorder, hearing loss, speech disorder, and seizures Mrs.Mahdia Samaha Kony
Prevention • Rh-negative mothers should be followed closely during pregnancy. • Special immune globulins, called RhoGAM, used to prevent RH incompatibility. • If the father of the infant is Rh-positive or if his blood type cannot be confirmed, the mother is given a mid-term injection of RhoGAM and a second injection within 72 hours of delivery. • These injections prevent the development of antibodies against Rh-positive blood. Mrs.Mahdia Samaha Kony
Women with Rh-negative blood type must receive this injection: • During every pregnancy • If they have a miscarriage or abortion • After prenatal tests such as amniocentesis and chorionic villus biopsy • After truma to the abdomen during a pregnancy Mrs.Mahdia Samaha Kony
Infections During Pregnancy • Cytomegalovirus (CMV) is one of most common (up to 1 in 1000) • More common among women working with young children (frequent exposure to urine, saliva, respiratory secretions) • 99% can be prevented with Good Hand washing Mrs.Mahdia Samaha Kony
Group B Streptococcus • 10 – 30 % of pregnant women carry bacterium in vaginal or rectal area • Causes 2/1000 babies to become sick or die in neonatal period • May be early (within 7 days) or late (from 7 days to 3 months) onset illness • 1/200 risk of infant becoming sick • Treated with IV antibiotics during L & D Mrs.Mahdia Samaha Kony