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Do Now. Write this down: B ritish King, Henry the VIII struggled to have a male heir (heir is the next person to claim the throne). He had multiple wives. Sometime he divorced them or had them killed for not giving him a male. Who is responsible for the sex of the child? Explain. Homework.
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Do Now • Write this down: • British King, Henry the VIII struggled to have a male heir (heir is the next person to claim the throne). He had multiple wives. Sometime he divorced them or had them killed for not giving him a male. • Who is responsible for the sex of the child? Explain
Homework • Friday – Notebook quiz. If you have been paying attention, taking notes and been on top of your homework you will do fine. • Due Monday: Read Chapter 15, section 1 pages 418-420. This will be the last thing we cover before Final Exams. This covers Selective Breeding (which is what Gattaca was all about)
As promised • For those of you that remembered, you asked for a pictures of Albinos: • First is albino tigers • Second is an albino person • First person of Asian ancestry • The second European ancestry
Write down the following • Write down the following questions and then answer. • Cystic Fibrosis- in your own words explain • 1. What does it do? • 2. How does it occur? • Sickle Cell Anemia • 1. What does it do? • 2. How does it impact?
Typhoid Mary • Irish cook Mary Mallon (1869-1938) was dubbed "Typhoid Mary" by the media after she infected dozens of people with the dreaded disease. • When Mallon worked as a cook at the turn of the century, typhoid fever was a highly contagious disease and a serious threat to the public health. Mallon was the first identified person who carried and spread the disease without ever exhibiting the symptoms. At least three deaths and 53 cases of typhoid were directly linked to her, with thousands of other probable cases.
Was she immune or just a carrier? • Some question as to whether she had CF in some form. Many in Europe (those most affected by CF) had developed a resistance to typhoid. The CF allele blocks the entry of bacterium typhoid. Those with a heterozygous for CF would develop an immunity.
Gene therapy • Gene therapy is a technique for correcting defective genes responsible for disease development (four types) • 1. A normal gene may be inserted into a nonspecific location within the genome to replace a nonfunctional gene. • 2. An abnormal gene could be swapped for a normal gene. • 3. The abnormal gene could be repaired through selective reverse mutation, and returns it normal function
Gene therapy continued • 4. The regulation (the degree to which a gene is turned on or off) of a particular gene could be altered.
Advantage of a genetic disorder? • Cystic Fibrosis – Thought to prevent Typhoid from occurring. In old Europe typhoid was common and the body seems to have adapted to prevent it by developing CF.
Sickle Cell Anemia • Remember that evidence points to higher survival rates for Africans where Malaria exists. Sickle Cell seems to have mutated and allowed Africans to survive in areas where Malaria exists
Nature’s way to deal with change • Organisms that face environmental change have 3 choices • 1. Adapt to the change in environment • 2. Move away from the new condition • 3. Die
Do now: • How would you or the person that bred Dachshunds create them? Meaning what are the steps – to make these “designer dogs?” • Answer – take a small breed of dog and breed with another small breed and then continually take the smallest of the litter and breed them. • They were designed to chase foxes during fox hunts. They purposely breed small dogs, each surviving litter only the smallest were breed with other small dogs of another litter of the same breed. • One of the earliest “Selective breeding”
