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What you need to know about NIH but were afraid to ask – a short guide August 14 , 2013

What you need to know about NIH but were afraid to ask – a short guide August 14 , 2013. Franziska Grieder, DVM, PhD Director Office of Research Infrastructure Programs/DPCPSI/OD National Institutes of Health. Office of Research Infrastructure Programs.

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What you need to know about NIH but were afraid to ask – a short guide August 14 , 2013

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  1. What you need to know about NIH but were afraid to ask – a short guideAugust 14, 2013 Franziska Grieder, DVM, PhD Director Office of Research Infrastructure Programs/DPCPSI/OD National Institutes of Health Office of Research Infrastructure Programs Office of Research Infrastructure Programs

  2. Overview • NIH: An overview • What you always wanted to know! • Applying for NIH grants • ORIP/DPCPSI • Training and other grant opportunities • Final thoughts

  3. NIH – An Overview and Introduction “Science in pursuit of fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to extend healthy life and reduce the burdens of illness and disability.”

  4. NIH Organizational Structure Office of the Director ORIP/DPCPSI National Institute on Aging National Institute on Alcohol Abuse and Alcoholism National Institute of Allergy and Infectious Diseases National Institute of Arthritis and Musculoskeletal and Skin Diseases National Cancer Institute National Institute of Child Health and Human Development National Institute of Dental and Craniofacial Research National Institute on Deafness and Other Communication Disorders National Institute of Diabetes and Digestive and Kidney Diseases National Institute on Drug Abuse National Institute of Environmental Health Sciences National Eye Institute National Institute of General Medical Sciences National Heart, Lung, and Blood Institute National Human Genome Research Institute National Institute of Mental Health National Institute of Neurological Disorders and Stroke National Institute of Nursing Research National Center on Minority Health and Health Disparities National Institute of Biomedical Imaging and Bioengineering National Center for Complementary and Alternative Medicine Fogarty International Center National Center for the Advancement of Translational Science National Library of Medicine NIH Clinical Center Center For Information Technology Center for Scientific Review These 3 Centers Do Not Issue Grants

  5. NIH – Understanding its dual nature NIH INTRAMURAL RESEARCH NIH is an institution NIH EXTRAMURAL RESEARCH • Supports >3,000 institutions worldwide; >300,000 scientists & research personnel • (~83% of NIH budget) • Awards issued to >100 countries • Clinical, Basic, & Translational Research • Supports >6,000 scientists • (~10% of NIH budget) • Primary location Bethesda, MD • A few labs throughout US

  6. http://grants.nih.gov

  7. NIH – Information you should know http://report.nih.gov/index.aspx

  8. NIH grant applications 101 Challenges of getting stared • What do you need to know? • Where do you start? • Who do you talk to? What do you read? • How do you make contact? • How do you effectively communicate? • What are your next steps?

  9. NIH grant applications 101 • What funding agency should you target? • Small or large • Federal or private • Local or national • What are your research interests? What questions do you address with your research? What type of investigations do you conduct and who are your mentors or collaborators?

  10. Grant applications – Funding agencies • DHHS, USDA, DOD, DOE • NIH, CDC, FDA, NSF • AVMA, ACLAM • Specific interest groups (e.g., cancer, JDRF, Rett syndrome) • Pharma (large and small) • Private foundations (e.g., Gates)

  11. NIH grant applications 101 • What funding agency should you target? • Small or large • Federal or private • Local or national • What are your research interests? • What questions do you address with your research? • What type of investigations do you conduct and who are your collaborators?

  12. NIH grant applications - Experience Past or current training, Research goals and interests, Collaborations • Research – clinical, translational, basic • Past training – PhD and post-doctoral, Masters research experience, practical post-doctoral experience • Setting – Research team with you in the lead, Collaboration with colleagues, Interdisciplinary collaboration, Mentored training experience • Future goals – Long-term support as tenured faculty, long- to mid-term support to establish research lab, mid- to short-term support to gain experience

  13. NIH grant applications - Planning • Time – 9 to 12 months under the best of circumstances • Success rate – the better you plan… (good ideas and well written applications are very important as well!) • Two-phase plan – gather information and contact NIH program officials …followed by writing…

  14. NIH – Program vs. Review • Program officials are managing grants, interact with and advise applicants, communicate with grantees, organize workshops, write program announcements and requests for program announcements • Review officials organize the peer-review group, assign applications to reviewers, edit summary statements

  15. Contacting the NIH Program Official • Identify the most appropriate individual • Review the NIH/Institute(s) web pages • Talk to senior colleagues • Contact individuals you know personally… • Make contact by sending an e-mail • Write a brief summary (one paragraph) • Provide a couple sentences about your-self • and your goals • Ask one or two questions • Follow-up with a phone call • After 2-3 days, call… • Refer back to your e-mail…

  16. Contacting the NIH Program Official(2) • Identify different institutes/programs that may fit • Ask for Program officers’ names • Explore the general match of your ideas/goals with the specific program goals • Ask specific questions • Avoid appearing aggressive (e.g., if you are told that the goal of your research does not fall within the Institutes’ program goals, don’t insist that it is a match) • Carefully listen to the advice!

  17. Contacting the NIH Program Official(3) • If you feel that you did not receive sufficient, satisfactory, complete advice… your next conversation with a subsequent program official may be more productive • Remember, the program official will likely attend the review meeting of your application • The Program official is the individual with who you will talk to after your application is review! • The Program official may know about programs you are not familiar with or about new announcements

  18. NIH grant applications – Additional Advice! • Be persistent! • Seek advice and guidance from senior colleagues • Work with a team • Start early and have experienced grant writers review your drafts… • Avoid unnecessary mistakes (e.g., missing information, misspellings, errors based on the recycling of an application, running out of time) • Seek advice from your institution (e.g., office of sponsored projects) • Participate in a grant writing course

  19. CSR & Referral and Review Anatomy of Grant Process- Summary Researcher Idea Institution Program Announcement or RFA Program Staff Collaborators Grant Application (R01, R03, R21, K01, K08, T32/35) Revision $ National Advisory Council Program Staff

  20. NIH Organizational Structure Office of the Director ORIP/DPCPSI National Institute on Aging National Institute on Alcohol Abuse and Alcoholism National Institute of Allergy and Infectious Diseases National Institute of Arthritis and Musculoskeletal and Skin Diseases National Cancer Institute National Institute of Child Health and Human Development National Institute of Dental and Craniofacial Research National Institute on Deafness and Other Communication Disorders National Institute of Diabetes and Digestive and Kidney Diseases National Institute on Drug Abuse National Institute of Environmental Health Sciences National Eye Institute National Institute of General Medical Sciences National Heart, Lung, and Blood Institute National Human Genome Research Institute National Institute of Mental Health National Institute of Neurological Disorders and Stroke National Institute of Nursing Research National Center on Minority Health and Health Disparities National Institute of Biomedical Imaging and Bioengineering National Center for Complementary and Alternative Medicine Fogarty International Center National Center for the Advancement of Translational Science National Library of Medicine NIH Clinical Center Center For Information Technology Center for Scientific Review These 3 Centers Do Not Issue Grants

  21. Office of Research Infrastructure Programs (ORIP)/Division of program coordination, planning, and strategic initiatives (DPCPSI) Immediate Office of the DPCPSI Director James M. Anderson, M.D., Ph.D. Office of Portfolio Analysis George Santangelo, Ph.D. Office of Program Evaluation and Performance Rosanna Ng, M.A. Office of AIDS Research Jack Whitescarver, Ph.D. Office of Research on Women’s Health Janine Clayton, M.D. Office of Behavioral and Social Sciences Research Robert Kaplan, Ph.D. Office of Disease Prevention David Murray, Ph.D. Office of Strategic Coordination Betsy Wilder, Ph.D. Office of Research Infrastructure Programs Franziska Grieder, D.V.M., Ph.D. Office of Dietary Supplements Division of Comparative Medicine Division of Construction and Instruments Office of Science Education 21

  22. Overview - Background NCRR = National Center for Research Resource ORIP = Office of Research Infrastructure Programs • A resource is defined as supplies from which benefit is produced. Typically resources are materials, money, services, staff, or other assets that are transformed to produce benefit and in the process may be consumed or made unavailable. • Infrastructure is basic physical and organizational structures needed for the operation of an enterprise, or the services and facilities necessary for an enterprise to function (incl. the resources such as personnel, buildings, or equipment) required for an activity. Office of Research Infrastructure Programs

  23. http://dpcpsi.nih.gov/orip

  24. DCM-Supported Grants and Activities • Center Grants • Grants • Animal and Biological Materials Resources • Cooperative Agreements • Animal and Biological Materials Resources • Research Program Grants • Investigator-initiated Hypothesis-driven awards • Conference/Meeting/Supplements • Training programs • Institutional and individual awards • SBIR/STTR

  25. DCM-Supported Institutional Training Awards for Veterinary Students/Veterinary Scientists (estim. 2013) • Number of Training Grants • T35 (Pre-DVM/Summer) - 18 grants • T32 (Pre-DVM/1 year) - 7 grants • T32 (Post-DVM/3 years) - 20 grants • Number of Trainees • T35 short term pre-DVM trainees ~ 148 • T32 DVM trainees ~ 83 (2012 = 94 trainees)

  26. ORIP – DCM programs • Disease model resources • High-quality, disease-free animals, specialized animal research facilities, and biological materials (e.g., antibody, snake venom) • Rodents, Fish, Non-human Primates, others (e.g., Pigs, Flies, Worm, Tissues and Cells) • Resource Centers with the infrastructure that support investigators’ needs • Caging or tanks • Technology • Collaboration

  27. Disease Model Resources and Programs • Mutant Mouse Resources • MMRRC (www.mmrrc.org), KOMP (www.komp.org) • Models for many conditions (e.g., Rett Syndrome, Werner Syndrome) • Swine Resource • NSRRC (www.nsrrc.org) (e.g., Gal-1, Fat-1) • Zebrafish Resource • ZIRC (www.zebrafish.org) (e.g., Fli-1, Fanconi Anemia) • C. elegans Resource • Fly Resource • Development of Technologies

  28. National Primate Research Centers (NPRCs) WashingtonNPRC OregonNPRC NewEnglandNPRC Wisconsin NPRC California NPRC Yerkes NPRC Tulane NPRC Southwest NPRC

  29. http://dpcpsi.nih.gov/orip

  30. ORIP – DCI programs • ORIP can provide Shared Instrumentation Grant (SIG) and High-End Instrumentation (HEI) Programs • HEI: PAR-13-101 (submission deadline Sept 13, 2013 ) • Award size $750k - $2.0M • Biennial receipt date • SIG has annual receipt date (usually in March); awards $100k - $600k • Key points: • Eligibility, Need, Enhancing NIH-funded research, Technical expertise, Administration and institutional commitment • One year funding appropriation

  31. ORIP – DCI programs • Construction Awards • Construction currently limited to G20 – Animal Facility Improvement Program PAR-13-219, Developing and Improving Institutional Animal Resources (submission deadline was Aug 2, 2013) • Goals: Renovate, repair, or Improve individual animal resources • Award size up to $500k • Note: No current C06 construction program (last active under ARRA during FY 2009/2010)

  32. Additional ORIP programs SBIR/STTR program • Consider looking into the SBIR/STTR programs! • Each NIH IC has an SBIR program • Set aside funds • In general much lower application pressure FOAs PA-13-234 (SBIR) and PA-13-235 (STTR) Submission deadline was Aug 5, 2013

  33. Final Thoughts • Funds are limited, but novel/innovative ideas get funded • Understand the rules (e.g., deadlines, requirements and limitations, guidelines) • Work in teams, with senior mentors • Always ask questions • Smart (young and experienced) scientists are needed to address the continuing challenges encountered by emerging and existing diseases. • Changing needs require scientists to constantly adapt • Accept the challenge! Office of Research Infrastructure Programs

  34. Questions?

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