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Genetics of human aggressive behaviour

Genetics of human aggressive behaviour. Heritability of aggression heritability accounted overall for about 50% of the variance (Miles and Carey 1997; Rhee and Waldman 2002). Heritability changed with time. female. male. Sex difference. two trinucleotide repeats.

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Genetics of human aggressive behaviour

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  1. Genetics of human aggressive behaviour

  2. Heritability of aggression • heritability accounted overall for about 50% of the variance • (Miles and Carey 1997; Rhee and Waldman 2002). • Heritability changed with time female male Sex difference two trinucleotide repeats Androgen receptor (AR) Aggressive behaviour

  3. Stress and the HPA axis Cortisol

  4. Aggressive behaviour • Sex Difference pathway • Stress pathway • The serotonin pathway • Low blood sugar pathway

  5. Sex difference Two trinucleotiderepeats association of shorter CAG repeats with muscular tension and with verbal aggression. Androgen receptor (AR)

  6. Stress and HPA- axis phthway 1 Dopamin-beta-hydroxylase (DBH) 2 Catechol - O - metthyltransferase (COMT) 3 Adrenergic receptors 4 Noradrenaline transporter (NET1, SLC6A2)

  7. The serotonin pathway Tryptrophan serotonin MAOA 5-hydroxy-indole acetic acid (5-HIAA) 5-HT1A, 5-HT1B autoreceptors pre-synaptic neuron aggressive behaviour

  8. Aggression and low blood sugar levels hypoglycaemia Aggressive behaviour

  9. Other Candidates Nitric oxide synthase (NOS1) Knock out (NOS1) Increased Aggressive behaviour Arginine vasopressin receptor (AVPR1A) No direct relationship to aggression has been demonstrated (Bachner-Melman et al. 2005; Kim et al. 2002; Wassink et al. 2004).

  10. Thank you

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