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III

A. Relative luciferase activity. Tg. 0. 50. 100. 150. 200. 250. 300. -. pGL3b. +. ALG12. -. -361/+11. +. -. -361/+11 m4. +. -. -361/+11 m5. +. -. -361/+11 m6. +. -. -361/+11 m7. +. III. I. II. B. Relative luciferase activity. Tg. 0. 5. 10. 15. 20. 25. 30.

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III

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  1. A Relative luciferase activity Tg 0 50 100 150 200 250 300 - pGL3b + ALG12 - -361/+11 + - -361/+11 m4 + - -361/+11 m5 + - -361/+11 m6 + - -361/+11 m7 + III I II B Relative luciferase activity Tg 0 5 10 15 20 25 30 I II III - ALG12 -361 +11 pGL3b + - -361/+11 m7 5’-ACCAATTGAGGCTCGCCACGAGAAGCCACCAATG-3’ + - -361/+11 m8 + AgactaTGAGGCTCGCCACGAGAAGCCACCAATG - -361/+11 m9 + ACCAATTGAGGCTCGCCACGAGAAGCCAgactaG C Relative luciferase activity Tg 0 5 10 15 20 25 30 35 CRELD2 -396 -209 - pGL3b + - -209/+396 3’-TGGTTAACTCCGAGCGGTGCTCTTCGGTGGTTAC-5’ + - TctgatACTCCGAGCGGTGCTCTTCGGTGGTTAC -209/+396 m1 + - TGGTTAACTCCGAGCGGTGCTCTTCGGTctgatC -209/+396 m2 +

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