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Dead End Filtration

Dead End Filtration. Design of a filtration system for biosynthetic insulin production. CHEE 450 March 30, 2009 Jeff DeMeza Blair Walker Richard Wong. Dead End Filtration Theory. Removes particulates larger than a specified pore size from filtrate Particulates accumulate as a filter cake

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Dead End Filtration

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  1. Dead End Filtration Design of a filtration system for biosynthetic insulin production CHEE 450 March 30, 2009 Jeff DeMeza Blair Walker Richard Wong

  2. Dead End Filtration Theory • Removes particulates larger than a specified pore size from filtrate • Particulates accumulate as a filter cake • Batch operation • Flow properties change with time • Filtrate flux • Pressure drop

  3. Dead End Filtration Theory Depth Filter

  4. Process Overview • Removes residual IBs, cell debris & biomass • Specifications • 1.25 hours filtration time, 23.3 kg filter cake/batch

  5. Design Consideration Determine Filter Area A filter surface = 13.8 m2 + 100% Safety Factor 3mm aste Permeate Filter

  6. Design Considerations Other considerations • Through Put • Pressure • Disposable Q = 1746 L/h A = 13.8m2 Pore Size = 0.2 μm Contact Venders & Product Information

  7. Combined sterile filter and casing design Dispose after each batch Most expensive filter Validation requirements are met Low capital costs Design Considerations Disposable Filter and Casing

  8. Disposable filter Reusable Stainless steel casing No contact of filtrate with casing Casing does not need to be cleaned between batches Initial validation required Large initial capital cost of casing Design Considerations Reusable Stainless Steel Casing

  9. Economic Analysis

  10. Economic Analysis Note: does not include validation costs

  11. Recommended Filter Reusable Stainless Steel Casing with Disposable Filter ? • Produced by Pall • ~ $2500 / batch • Area surface = 14m2 • P = 3.5 bar • Pore size = 0.2 • Quattro Flow pump manufactured by Triangle Process Equipment

  12. Questions?

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