Let’s really begin!

1. Let’s really begin!

2. Chemistry Textbook: 第8版http://edu.cengage.co.uk/instructors/product.aspx?isbn=0495829927 第7版http://college.cengage.com/chemistry/zumdahl/chemistry/7e/site_index.html Chemistry animation: http://www.wpunj.edu/icip/sec/CHEMgenANIM.htm Chemistry for students: http://www.chem1.com/chemed/genchem.shtml Chemguide: http://www.chemguide.co.uk/index.html#top Google http://www.google.com

3. Chemistry: Etymology • Egyptian alchemy [3,000 BCE – 400 BCE], formulate early "element" theories such as the Ogdoad. • Greek alchemy [332 BCE – 642 CE], the Greek king Alexander the Great conquers Egypt and founds Alexandria, having the world's largest library, where scholars and wise men gather to study. • Arabian alchemy [642 CE – 1200], the Arabs take over Alexandria; Jabir is the main chemist • Chinese Alchemy [~1000 BC-present, Yin/Yang, I Ching, Five Elements, Qi, Void, Nothingness, Taoism] • European alchemy [1300 – present], Pseudo-Geber builds on Arabic chemistry • Chemistry [1661], Boyle writes his classic chemistry text The Sceptical Chymist • Chemistry [1787], Lavoisier writes his classic Elements of Chemistry • Chemistry [1803], Dalton publishes his Atomic Theory

4. Chemistry: Definition Alchemy (330) – the study of the composition of waters, movement, growth, embodying, disembodying, drawing the spirits from bodies and bonding the spirits within bodies (Zosimos) Chymistry (1661) – the subject of the material principles of mixt bodies (Boyle) Chymistry (1663) – a scientific art, by which one learns to dissolve bodies, and draw from them the different substances on their composition, and how to unite them again, and exalt them to an higher perfection (Glaser). Chemistry (1730) – the art of resolving mixtures, compound, or aggregate bodies into their principles; and of composing such bodies from those principles (Stahl). Chemistry (1837) – the science concerned with the laws and effects of molecular forces (Dumas). Chemistry (1947) – the science of substances: their structure, their properties, and the reactions that change them into other substances (Pauling). Chemistry (1998) – the study of matter and the changes it undergoes(Chang).

7. Contour plot of the Cooper-pair density of vortex-antivortex states found in Co/Pt magnetic dots.

9. the way you live, Houses hospitals HighriseSs Processed food and drink medicine Cell phone

10. the way you travel, Cars Trains Airplanes Ships

11. the way you learn, Computers Internet E-classroom

12. Chemistry changes what you wear, socks clothes shoes raincoats Caps and hats

13. the way you work, Automation Mass production Work at home

14. the way you think, Integrative thinking Prospective thinking Global thinking Profound thinking

15. and many more ……

16. Why can you perceive? Ion channels are integral membrane proteins through which ions can cross the membrane. Most channels are specific for one ion; whereas that ion passes through relatively quickly, other similar ions pass through very infrequently.[13] For example, although potassium and sodium ions have the same charge and differ only slightly in their radius, potassium channels allow few sodium ions through, and vice versa. The pore through which the ion passes is typically so small that ions must pass through it alone and single-file.[14] Channels are either fully open or fully closed. When the channel is open, ions flow through it by passive transport, i.e., at a rate determined by the membrane potential Vm and concentration difference across the membrane.[15] The action potential is a manifestation of different ion channels opening and closing at different times.[16] All-atom figure of the open potassium channel, with the potassium ion shown in purple in the middle. When the channel is closed, the passage is blocked. A channel may have several different states (corresponding to different conformations of the protein), but each such state is either open or closed. In general, closed states correspond either to a contraction of the pore—making it impassable to the ion—or to a separate part of the protein stoppering the pore. For example, the voltage-dependent sodium channel undergoes inactivation, in which a portion of the protein swings into the pore, sealing it.[17] This inactivation shuts off the sodium current and plays a critical role in the action potential. Ion channels can be classified by how they respond to their environment.[18] For example, the ion channels involved in the action potential are voltage-sensitive channels; they open and close in response to the voltage across the membrane. Ligand-gated channels form another important class; these ion channels open and close in response to the binding of a ligand molecule, such as a neurotransmitter. Other ion channels open and close with mechanical forces. Still other ion channels—such as those of sensory neurons—open and close in response to other stimuli, such as light, temperature or pressure.

17. Why can you see? The rhodopsin or iodopsin in the outer segment absorbs a photon, changing the configuration of a retinalSchiff basecofactor inside the protein from the cis-form to the trans-form, causing the retinal to change shape. This results in a series of unstable intermediates, the last of which binds stronger to the G protein in the membrane and activates transducin, a protein inside the cell. This is the first amplification step - each photoactivated rhodopsin triggers activation of about 100 transducins. (The shape change in the opsin activates a G protein called transducin.) Each transducin then activates the enzyme cGMP-specific phosphodiesterase (PDE). PDE then catalyzes the hydrolysis of cGMP. This is the second amplification step, where a single PDE hydrolyses about 1000 cGMP molecules. (The enzyme hydrolyzes the second messengercGMP to GMP) With the intracellular concentration of cGMP reduced, the net result is closing of cyclic nucleotide-gated ion channels in the photoreceptor membrane because cGMP was keeping the channels open. (Because cGMP acts to keep Na+ion channels open, the conversion of cGMP to GMP closes the channels.) As a result, sodium ions can no longer enter the cell, and the photoreceptor hyperpolarizes (its charge inside the membrane becomes more negative). (The closing of Na+ channels hyperpolarizes the cell.) This hyperpolarization means that less glutamate is released to the bipolar cell than before (see below). (The hyperpolarization of the cell slows the release of the neurotransmitter glutamate, which can either excite or inhibit the postsynaptic bipolar cells.) Reduction in the release of glutamate means one population of bipolar cells will be depolarized and a separate population of bipolar cells will be hyperpolarized, depending on the nature of receptors (ionotropic or metabotropic) in the postsynaptic terminal (see receptive field).

18. Why can you hear?

19. Why can you taste?

20. Why can you smell? Olfactory epithelium In vertebrates smells are sensed by olfactory sensory neurons in the olfactory epithelium. The proportion of olfactory epithelium compared to respiratory epithelium (not innervated) gives an indication of the animal's olfactory sensitivity. Humans have about 10 cm² of olfactory epithelium, whereas some dogs have 170 cm2. A dog's olfactory epithelium is also considerably more densely innervated, with a hundred times more receptors per square centimetre. Molecules of odorants passing through the superior nasal concha of the nasal passages dissolve in the mucus lining the superior portion of the cavity and are detected by olfactory receptors on the dendrites of the olfactory sensory neurons. This may occur by diffusion or by the binding of the odorant to odorant binding proteins. The mucus overlying the epithelium contains mucopolysaccharides, salts, enzymes, and antibodies (these are highly important, as the olfactory neurons provide a direct passage for infection to pass to the brain). In insects smells are sensed by olfactory sensory neurons in the chemosensory sensilla, which are present in insect antenna, palps and tarsa, but also on other parts of the insect body. Odorants penetrate into the cuticle pores of chemosensory sensilla and get in contact with insect Odorant binding proteins (OBPs) or Chemosensory proteins (CSPs), before activating the sensory neurons. [edit] Receptor neuron The process of how the binding of the ligand (odor molecule or odorant) to the receptor leads to an action potential in the receptor neuron is via a second messenger pathway depending on the organism. In mammals the odorants stimulate adenylate cyclase to synthesize cAMP via a G protein called Golf. cAMP, which is the second messenger here, opens a cyclic nucleotide-gated ion channel (CNG) producing an influx of cations (largely Ca2+ with some Na+) into the cell, slightly depolarising it. The Ca2+ in turn opens a Ca2+-activated chloride channel, leading to efflux of Cl-, further depolarising the cell and triggering an action potential. Ca2+ is then extruded through a sodium-calcium exchanger. A calcium-calmodulin complex also acts to inhibit the binding of cAMP to the cAMP-dependent channel, thus contributing to olfactory adaptation. This mechanism of transduction is somewhat unique, in that cAMP works by directly binding to the ion channel rather than through activation of protein kinase A. It is similar to the transduction mechanism for photoreceptors, in which the second messenger cGMP works by directly binding to ion channels, suggesting that maybe one of these receptors was evolutionarily adapted into the other. There are also considerable similarities in the immediate processing of stimuli by lateral inhibition. Averaged activity of the receptor neurons can be measured in several ways. In vertebrates responses to an odor can be measured by an electroolfactogram or through calcium imaging of receptor neuron terminals in the olfactory bulb. In insects, one can perform electroantenogram or also calcium imaging within the olfactory bulb. The receptor neurons in the nose are particularly interesting because they are the only direct recipient of stimuli in all of the senses which are nerves. Senses like hearing, tasting, and, to some extent, touch use cilia or other indirect pressure to stimulate nerves, and sight uses the chemical rhodopsin to stimulate the brain.

21. How to eat properly?

22. How to drink correctly?

23. Chemistry helps find the best better half

24. Turn yourself into a genius via knowledge, thinking and practicing

25. I hope you agree!

26. In tranquil night, in deep meditation, I experience physical states, I feel chemical reactions… I see lights, flames, colors, burning, excitation, explosion… I see warmth, brightness, beauty, ease, stretch, softness,simplicity, tranquility… Iseechill,darkness,ugliness,stress,apprehension,violence,complexity,commotion… Ihearwords notcarriedbyvoiceorshape, reasons notderivedfrominductionorreduction… Iheardeclarations, demonstrations, interpretations…. 靜夜，深思，物理狀態，化學變化……光，火，色，燃燒，激發，爆炸……溫暖，明亮，美麗，輕鬆，舒展，柔和，簡樸，寧靜……冰凍，黑暗，醜陋，緊張，焦慮，暴烈，複雜，喧囂……無聲無形之詞，無匯無衍之理……宣告，演示，解說……

27. How a typical Gen Chem class is composed? • Introduction, terms, tables, diagrams, equations • Real Stories • Chemistry in Plays, Movies and Novels • Case Studies • Questions and Exercises in Classroom • Discussion • Questions and Answers • Quizzes