Tukysa (Tucatinib) Availability in India | 9310090915

1. Tukysa The Personalized Medicine That’s Saving Lives • INDICATION AND USAGE Tukysa is a cancer medicine that is a kinase inhibitor. This potent drug is used to treat HER2-positive breast cancer, which is locally advanced or has spread to other parts of the body. This means the cancerous cells produce a protein on their surface, HER2, which stimulates the growth of cancer. The medicine Tukysa is used with two other medicines, capecitabine and trastuzumab. It is used after at least two other treatments for HER2-positive cancer have already been given and tried. This efficient drug is within reach in the market, and that too at affordable rates as Tukysa price is economical. For more information about the drug, you can call us at +91 9310090915 and ask for further detail regarding Tukysa. • DOSAGE STRENGTH It is available as yellow, film-coated, oval Tukysa 150 mg tablets and round 50 mg tablets containing tucatinib, its active pharmaceutical ingredient. This drug can only be obtained with a prescription, and treatment should be started and supervised by an expert experienced in giving cancer treatments. Tukysa can cause severe hepatotoxicity, and based on the severity of hepatotoxicity, the dose might be interrupted or reduced, and in some cases, it is permanently discontinued. So, the dose must be selected by the doctor only in order to have better and enhanced effects with the least toxicity. • DOSAGE AND ADMINISTRATION Tukysa is given orally, that is, by mouth, and the recommended dose is 300 mg twice a day. Patients are also treated with capecitabine and trastuzumab on specific days of a 21-day cycle. Treatment can continue as long as cancer does not get worse, there is any progression and side effects are bearable. The doctor recommends a reduced dose of Tukysa if certain side effects occur, or the treatment may be temporarily or permanently stopped. For patients with severe hepatic impairment, taking a dosage of 200 mg orally twice daily is recommended. To know more about Tukysa tablet cost in India, you can visit us at www.indianpharmanetwork.in. • MECHANISM OF ACTION The active substance in Tukysa is tucatinib. It is a type of cancer medicine called a tyrosine kinase inhibitor. Tucatinib inhibits the phosphorylation of HER2 and HER3, which results in the inhibition of downstream MAPK and AKT signaling and cell proliferation. It showed antitumor activity in HER2- expressing tumor cells by attaching to the HER2 protein on the cancer cells, so its action is blocked. As HER2 helps cancer cells to grow and divide, thus blocking it helps to stop these cells from growing. This causes them to die, controlling the growth of cancer.

2. The desired effect can be obtained by taking a certain dose of the drug as recommended by the doctor. To buy Tukysa tablets online at affordable rates, you can visit us or call us at +91 9310090915. • ADVERSE DRUG REACTION Like any other cancer drug, some Tukysa side effects are accompanied by the ill effects of the drug. The most common side effects associated with Tukysa are nose bleeds, diarrhea, nausea, vomiting, stomatitis which is inflammation of the mouth, rash, arthralgia, palmar-plantar erythrodysesthesia, anemia, increases in the blood levels of liver enzymes ALT and AST and bilirubin, and weight loss. This may affect more than 1 in 10 people using Tukysa. Other more serious side effects caused due to Tukysa, which are in more than 1 in 20 people using the drug, are diarrhea and increased ALT and AST, hepatotoxicity, nausea and vomiting may also be serious and can be fatal. • STORAGE TUKYSA 50 mg and 150 mg tablets are supplied as yellow, film-coated, round and oval tablets, respectively. Each tablet is debossed with “TUC” on one side and “50” on the other side for 50 mg and “150” in case 150 mg is packaged. It is stored at a controlled room temperature from 20ºC to 25ºC (68ºF to 77ºF). Dispense to the patient in the original container only. It is stored in the original container to protect it from moisture. The cap should be securely replaced each time after opening. Desiccant needs not to be discarded. Once opened, use within 3 months. Discard any unused tablets 3 months after opening the bottle. To seek the price of TUKYSA in India, you can call us at +91 9310090915. • DRUG INTERACTIONS Although the cost of tucatinib is affordable, it has some following drug interactions that need to be known before using the drug. For more detail, ask your doctor. Strong CYP3A Inducers or Moderate CYP2C8 Inducers: concomitant use of strong CYP3A inducers or moderate CYP2C8 inducers should be avoided. Strong CYP2C8 Inhibitors: Avoid concomitant use as it reduces the Tukysa dose if concomitant use cannot be avoided. CYP3A Substrates: Avoid co-administering use with CYP3A substrates. As minimal concentration changes may lead to serious or life-threatening toxicities, which can be fatal. P-gp Substrates: P-gp substrates dose should be reduced, as minimal concentration changes may lead to serious or fatal toxicities. https://helpforheallth.blogspot.com/2023/04/tukysa-breakthrough-cancer-drug.html • AVAILABILITY IN MAHARASHTRA Tukysa has an active pharmaceutical ingredient, tucatinib, which is potently used to treat adult patients with HER2-positive breast cancer in combination with some other drugs. It is not known if Tukysa is safe and effective for children. Before taking Tukysa, it is important to tell the healthcare provider about any liver problem or pregnancy, as it can cause hypersensitivity and harm to the fetus. It is available in Maharashtra, and the cost of Tuksya in Mumbai is pocket efficient. To know

3. more about the pricing and further details, you can contact us by visiting https://www.indianpharmanetwork.in/. • PRICE IN NOIDA While taking the drug, it is advised to patients to swallow Tukysa tablets whole and not to chew, crush, or split them before swallowing. If the tablet is broken, cracked, or not otherwise intact, it is advised not to use it and discard it immediately. Patients are advised to take Tukysa approximately 12 hours apart and at the same time each day, with or without a meal. If the patient vomits or misses a dose of Tukysa, it is instructed to take the next dose at its usual scheduled time. When Tukysa is given in combination, the recommended dosage of capecitabine is 1000 mg/m2 orally twice daily, taken within 30 minutes after a meal. Capecitabine and Tukysa can be taken at the same time. You can readily purchase this drug at cheaper rates as the cost of Tucatinib in Noida is much more reasonable and pocket efficient. • 1.Pregnancy- USE IN SPECIFIC POPULATION As shown in some animal studies and the method of action of tucatinib, it is found that it can potentially cause fetal harm if taken by pregnant women. So it is advised not to take it by a pregnant woman, and always tell the healthcare provider if you are pregnant before starting the treatment. Lactation- There is no such data on the presence of tucatinib in milk. Metabolites of TUKSYA in human milk or their effects on the breastfed child or milk production still need to be discovered as there are no studies present to show it. But because of the potential for serious adverse reactions in breastfed children, it is advised not to breastfeed. For further information about the use of the drug in a specific population and Tukysa cost in India, you can visit us at https://www.indianpharmanetwork.in/ COMPOSITION The active ingredient of Tukysa is tucatinib, and the list of inactive ingredients contains copovidone, crospovidone, sodium chloride, potassium chloride, sodium bicarbonate, colloidal silicon dioxide, magnesium stearate, and microcrystalline cellulose in tablet core. In Tukysa tablet coating, a yellow film coat is made up of polyvinyl alcohol, titanium dioxide, macrogol/polyethylene glycol, talc, and yellow iron oxide non-irradiated. It is to note that the use of Tukysa in combination with capecitabine and trastuzumab is not recommended in patients with severe renal impairment because, in the case of patients with severe renal impairment, capecitabine is contraindicated. DESCRIPTION Tucatinib is a kinase inhibitor. The molecular weight of Tucatinib is 480.52 g/mol. Tucatinib is supplied as 50 mg and 150 mg film-coated tablets for oral use. Each Tukysa 50 mg tablet contains potassium and sodium. To know more about Tukysa tablets cost, you can visit us at Indian Pharma Network; we will be happy to help you.

4. • INDIAN PHARMA NETWORK This medicine is under additional monitoring, which states that it is monitored even more intensively than other medicines. As it is therapeutically used in Breast Neoplasms and Neoplasm Metastasis, it requires extensive care. This drug has been shown to improve the length of time patients with advanced or metastatic HER2-positive breast cancer lived without their disease worsening. You can get this drug under a prescription and from an authorized dealer. Indian Pharma Network is among the certified dealers and Tukysa suppliers in India, which has been supplying genuine life- saving drugs for more than 8 years globally. • EFFECT ON FERTILITY It is advised in females of reproductive potential to use effective contraception during treatment with tucatinib and for at least 1 week after the last dose. Male patients are advised with female partners of reproductive potential to use effective contraception during treatment with tucatinib and for at least 1 week after the last dose. Based on findings from animal studies, it is found that Tukysa may impair male and female fertility. To know more about the drug, its effect, and Tucatinib cost, you can visit us at Indian Pharma Network or call +91 9310090915 and ask for further details regarding Tuksya. • WARNINGS AND PRECAUTIONS Diarrhea: Severe diarrhea, including dehydration and acute kidney injury, which could be fatal and cause death, has been reported. It is advised to administer antidiarrheal treatment as clinically indicated. The dose can be interrupted, reduced, or permanently discontinued for TUKYSA based on severity. Hepatotoxicity: Severe hepatotoxicity has been reported on TUKYSA. Monitoring of ALT, AST and bilirubin before starting TUCATINIB is done every 3 weeks during treatment and as clinically indicated. Interrupt dose, dose reduction, or permanently discontinue TUKYSA based on severity. Embryo-Fetal Toxicity: TUKYSA can actively cause fetal harm. It is advised to patients of the potential risk to a fetus and to use effective contraception. To buy Tukysa online in India, you can call us at +91 9310090915 or visit us at Indian Pharma Network. Source - https://helpforheallth.blogspot.com/2023/04/tukysa-breakthrough-cancer-drug.html