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Conflict of Interest Disclosure <Hidezo> <Mori>, <MD>

Conflict of Interest Disclosure <Hidezo> <Mori>, <MD>. Has no real or apparent conflicts of interest to report. Visualization of Perforating Branches of Cerebral Arteries Toward Clinical Evaluation of Vascular Disease and Alzheimer’s-overlap Syndrome.

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Conflict of Interest Disclosure <Hidezo> <Mori>, <MD>

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  1. Conflict of Interest Disclosure<Hidezo> <Mori>, <MD> Has no real or apparent conflicts of interest to report.

  2. Visualization of Perforating Branches of Cerebral Arteries Toward Clinical Evaluation of Vascular Disease and Alzheimer’s-overlap Syndrome Hidezo Mori1, Naoto Fukuyama1, Yoshimori Ikeya1, Toshiharu Fujii1, Chiharu Tanaka1, Yuko Tsukamoto1, Shunya Takizawa1, Keiji Umetani 2. 1Departments of Physiology, Neurology and Cardiology, Tokai University School of Medicine, Ishehara, 2Division of Reserch and Utilization, JASRI, Sayo-cho, Japan

  3. Background Vascular cognitive impairment (VCI) is characterized By sub-corticalwhite-matter lesion on MRI/CT, and often associated with Alzheimer Disease.

  4. Purpose of Present Study The present study examined whether synchrotron radiation (SR) microangiography can detect functional DM microangiopathy and visualize directly the perforating branches of cerebral arteries (PBCA) in rat models.

  5. An illustration of an experimental arrangement for synchrotron microangiography in rats Langendorf Synchrotron （１ ⇒ ８ ＧｅＶ） B A 線形加速器 （０ ⇒１ ＧｅＶ） 8GeV Electron Beam Monochromatic X-Ray Bending magnet object Slitt Synchrotron radiation Single-clystal monochromator MI heart X-ray Shutter X-Ray Saticon Camera

  6. Mass Absorption Coefficient Plotted Against Photon Energy Monochromatic x-ray (cm2/kg) 1000 100 10 1 0.1 Conventional white x-ray Mass absorption coefficient K-edge K 吸収端 Mass attenuation coefficient (cm2/g) iodine ヨード bone bone 筋　肉 muscle 0 20 40 60 80 100 120 140 Photon energy (KeV) （keV） Photon energy

  7. Protocol-1 In order to determine whether fingertip synchrotron radiation (SR) microangiography has enough spatial resolution to quantitate arterioles (20-200 μm in diameter) , we measured diameter reduction as arteriolar branching in fingertip microvessels. Next, we compared the arteriolar diameter changes induced by Ach administration between control and DM rats.

  8. Baseline Ach 100 μm Microvessel of Fingertip # ＊Mother ‡Daughter1 ‡ ＊ #Daughter 2 a-1 a-2 b-1 b-2

  9. n = 38 Lumen Diameter of 1st Daughter Artery Lumen Diameter of 2nd Daughter Artery Mother and 1st Daughter Artery Mother and 2nd Daughter Artery

  10. P < 0.016 P < 0.024 n = 25 n = 37 142.4 ± 61.9 190.9 ± 73.5 201.6 ± 83.0 160.4 ± 67.9 Baseline AchStress Baseline AchStress Normal Group DM Group

  11. Protocol-2 Whether SR microangiography can visualize perforating branches of cerebral arteries (PBCA) in rat models. By injecting contrast materials selectively into internal carotid artery SR microangiography was applied to visulaize cerebral microvessles in control and DM rats.

  12. Perforating branches of cerebral arteries in normal rat

  13. Perforating branches of cerebral arteries in DM rat

  14. Conclusion SR microangiography can detect functional DM microangiopathy the both in fingertip arterioles and perforating branches of cerebral arteries in rats, and could be useful for clinical evaluationof vascular disease and Alzheimer’s-overlap syndrome.

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