BIOMEDICA LIFE SCIENCES SA

1. BIOMEDICA LIFE SCIENCES SA Expanding a commercial SME specializing in radiopharmaceuticals and high-tech medical imaging instrumentation into a dynamic group of Biotechnology companies

2. BIOMEDICA LIFE SCIENCES SAEstablished in 1994Total number of employees: 29 2003revenue from sales 4,016 mil € EBT 0,9 mil € Coupling BIOMEDICA’s management and marketing resources and expertise with excellence in biotechnological research of Greek Research Institutes and University Laboratories Main concept for the expansion:

3. Strategy Main Points and Objectives 1. Establishing the company’s R&D base through the collaboration with research groups in National Research Centres and Universities 2. Organizing and managing a state-of-the-art Radiopharmaceuticals Production Unit (GMP) based on the infrastructure and know-how of NCSR “Demokritos” 3. Designing, conducting and funding of multicenter clinical trials in Greece and abroad 4. Expanding into Molecular Diagnostics & Genetic Testing

4. Establishing the R&D BaseCollaborating with the Greek Research CommunityI. Direct funding of novel research ideas in Radiopharmacy and Radiodiagnostics 1. Radiolabeled Biomolecules in Diagnosis and Therapy • Tc99m labelled bombesin, minigastrin and neurotensin analogues Principal Investigators: A. Varvarigou, NCSR “Demokritos” T. Maina, B. Nock, NCSR “Demokritos” Greek patents granted – European patents pending • Tc99m labelled YIGSR for radiodiagnosis & immunotherapy Principal Investigator:G. Koliakos, University of Thessalonica Greek patent granted – European patent granted 2. Peptide Design and Synthesis Principal Investigator: P. Cordopatis, University of Patras Greek patents granted – European patents pending

5. II. Participating as co-sponsor and/or end-user in selected research programs funded by GSRT andEU • EKBAN2003-2006«Τεχνητά Χρωμοσώματα Εντομοιών (ΤΕΧΠΕΝ) και Τεχνολογίες για Γονιδιακή Θεραπεία και Συνεχή Υψηλού Επιπέδου Έκφραση Θεραπευτικών Πρωτεϊνών σε εντομικά Συστήματα Παραγωγής»,ΕΚΕΦΕ «Δημόκριτος»,Ινστιτούτο Pasteur, Biomedica, 582.000 € (budget of project, Biomedica participation 245.000 €) • ΗΡΩΝ 2003-2006«Ανάπτυξη και αξιολόγηση ραδιοεπισημασμένων βιομορίων για διάγνωση ή/και θεραπεία νεοπλασιών διαφόρων μορφών»Biomedica, 264.000 € (granted by 50%) • ΠΕΝΕΔ – ΔΙΑΚΡΑΤΙΚΕΣ ΣΥΝΕΡΓΑΣΙΕΣ

6. Biomedica Research Personnel May 2004 BIOMEDICA Funded Research Programs: 7 full time positions – 4 PhDs Co-Sponsored Research Programs: 5 full time positions– 4 PhDs

7. 2. Organizing and Managing a Radiopharmaceutical Production Unit A strategic alliance between BIOMEDICA and the Institute of Radioisotopes & Radiodiagnostic Products has been approved by the Board of Directors of NCSR “Demokritos” in May 2004

8. Joint Venture • Organization and Management of the Institute’s unique Infrastructure • Implementation of Good Manufacturing Practice (GMP) Protocols

9. Production of selected highly demanded radiopharmaceuticals in Greece and abroad • Pilot production of novel products for clinical trials • Providing specialized GMP lyophilization services to third parties • Providing education and training

10. NCSR “Demokritos” Infrastructure • Class 100 lyophilization clean room • Radiochemical – Radiobiological Quality Control Labs • Hot-Cells A joint BIOMEDICA & NCSR “Demokritos” team will carry out development, production and QC of radiopharmaceuticals

11. 4. Expanding into Molecular Diagnostics & Genetic Testing BioGenomica S.A. Centre for Genetic Testing and Analyses A spin-off Company of NCSR “Demokritos” established in February 2004 The company’s business plan has been successfully incorporated in the PRAXE Phase B Program of GSRT with a total budget of 2 mil €.

12. BioGenomica SACentre for Genetic Testing and Analyses a spin-off company of NCSR “Demokritos” Genetic testing for predisposition to hereditary diseases Cancer -Neurological and Psychiatric Disorders - Rare Diseases DNA sequencing tailoring specific laboratory needs Food industry – Public health

13. Providing services to hospitals, clinics and diagnostic centres in Greece and abroad • Participation in international genetic testing networks • Providing services to the food and agricultural industry

14. June 2004: total number of employees: 6 (3 PhDs) State-of-the-art instrumentation: Automated DNA Sequencing, dHPLC, Real-time PCR and DNA microarray-based technologies • European Molecular Quality Network evaluation and accreditation

15. BioGenomica Research Establishment of International Scientific Advisory Board • Design of clinical research protocols jointly with medical centers and collaborative groups and networks • Participation in large-scale genetic epidemiology studies • Incubation of basic science, biochemical and biophysical research projects jointly with Universities and Research Institutes