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Iontophoresis Anti-aging Solution I

Iontophoresis Anti-aging Solution I. ROCKET GROUP. 2011. January, by Jason A. Choi jason@rocket.co.kr / +82-2-3451-5794. Rocket Group.

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Iontophoresis Anti-aging Solution I

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  1. Iontophoresis Anti-aging Solution I ROCKET GROUP 2011. January, by Jason A. Choi jason@rocket.co.kr / +82-2-3451-5794

  2. Rocket Group Rocket Electric has been recognized as one of the top high-tech thin film battery manufacturers with solid financials, technology and quality control system. 2009 marks Rocket’s entry into the international cosmetics market. Rocket aims to become the world no.1 company in thin battery field by 2015. Rocket Electric is positioned for international growth in the areas of functional cosmetics patches, therapeutic patches and slimming patches. Rocket Electric ensures the uniformity of the patches with over 65 years quality control experience for global leading companies.

  3. Iontophoresis Mechanism Iontophoresis is the ability of an electric current to cause charges particles to move. Iontophoresis delivers medication transdermally (both locally and systemically) using electric current to ionize drug molecules and propel them through the skin. In a patch form, two adjacent electrodes set up an electrical potential to drive charged compounds through the skin. This is particularly important for the transdermal delivery of peptides and oligonucleotides due to the polar groups associated with these molecules. The real attraction of iontophoresis is that is does not rely on a concentration gradient and is not affected by individual differences in skin permeability. The technology also has the potential to deliver pulses, for example, hormonal treatments, simply by switching the current on or off.

  4. Key Features & Structure • Cutting-Edge Technology • : International patent applied • Most Effective Mothoed • : Reduce wrinkles up to 80% • Instant Effect • : Visual Difference in 1 hour • Safe • : Will pass RIPT(Repeated Insult Patch • Test) in Feb. 2011 by FDA authorized Lab. • Environment-Friendly • : No toxic, no heavy metal, no over-heating, • no explosive materials (The design & size of eye patch can be customized)

  5. 12 Active Ingredients (i) • Allantoin • Allantoin is a healing, moisturizing, soothing and anti-irritating, keratolytic and non-toxic agent useful in • dermatological, cosmetic and veterinary preparation. Allantoin is a valuable cell-proliferating healing agent which • stimulates healthy tissue formation. • Dipotassium Glycyrrhizate • The potassium salt of glycyrrhizic acid, also known as licorice root, dipotassium glycyrrhizate is • an excellent skin lightener and brightener. • Arginine • classified as a semiessential or conditionally essential amino acid, Arginine quicken the repair time of damaged cells. • Sodium Hyaluronate (Hyaluronic Acid) • Sodium Hyaluronate plays a fundamental role in tissue repair processes by stabilizing the coagulation matrix and • controlling its degradation, favoring the recruitment of inflammatory cells. • Adenosine • Adenosine advantageously allows for the enhancement of the skin condition. This results in skin that shows a less • wrinkled, rough, or dry complexion. • Camellia Sinensis (Green Tea) Leaf Extract • Camellia Sinensis (Green Tea) Leaf Extracts reduce redness and suppress skin inflammation and irritation while • providing powerful antioxidant properties that help protect cells from free radical damage initiated by environmental • factors.

  6. 12 Active Ingredients (ii) • EGF (Human Oligopeptide-1) • One of the important growth factors in human body, it can accelerate DNA replications and the growth of the cells. It • reduces the wrinkles. • Soluble Collagen • Collagen is the main protein of connective tissue. It is one of the support proteins, providing skin with appropriate • tightness, moisturisation, springiness, elasticity and suppleness. • Salix Alba (Willow) Bark Extract • Salix Alba (Willow) Bark Extract containing 15% salicylic acid, will decrease inflammation, increase skin cells • turnover, prevent pore clogging and kill propionibacterium acnes. • Ginkgo Biloba Leaf Extract • Gingko biloba helps to increase circulation, prevent capillary fragility and helps to boost collagen formation and create • fibroblast, which makes it ideal to use in rejuvenating skin care products. • Bacillus/Soybean Ferment Extract • Bacillus/Soybean Ferment Extract forms the visco-elastic film on the skin providing proven skin-smoothing properties. • It is a natural moisturizing factor, having a high capacity of moisture retention. Aids recovery of skin damage and • irritation. • Actinidia Chinensis (Kiwi) Fruit Extract • Actinidia Chinensis (Kiwi) Fruit Extract stimulating effects on cell proliferation via enhanced growth factor receptors, • energy production, and collagen synthesis of human keratinocytes, fibroblasts, and skin equivalents.

  7. Treatment Mechanism 1. Iontophoresis patch applied conjunction with anti-aging serum: Self-activates 2. Micro-current pushed ionized active ingredients deep & fast onto the skin EG) Positively(+) ionized active ingredients repelled by anode(+). 3. Enhance delivery of active ingredients Enhance delivery of active ingredients onto dermis

  8. Micro-Current Analysis 5 ㎂/㎠ 15 ㎂/㎠ 25 ㎂/㎠ 0 ㎂/㎠ 2 ㎂/㎠ Stratum Corneum Stratum Lucidum Stratum Granulsum Stratum Spinosum Stratum Basale Dermis When micro-current is too little, active ingredients can not be delivered onto dermis When micro-durrent is more than 5㎂/㎠, active ingredients are delivered onto dermis When micro-current is too much, the skin might be Damaged by burn.

  9. Iontophoresis Patches

  10. References 1. Abell E, Morgan K : The treatment of idiopathic hyperhidrosis by glycopyrronium bromide and tap water iontophoresis. Br J Dermatol 91:45-60, 1974. 2. Agostinucci J, Powers WR : Motorneuron excitability modulation after desensitization of the skin by iontophoresis of lidocaine hydrochloride. Arch Phys Med Rehabil 73:190-194, 1992. 3. Akins DL, Meisenheimer JL, Dobson RL : Efficacy of the drionic unit in the treatment of hyperhidrosis. J Am Acad Dermatol 16:828-833, 1974. 4. Basford JR : Electrical therapy. In: Krusen's Handbook of Physical Medicine and Rehabilitation. Kottke FJ and Lehmann JF (Ed). 4th ed., WB Saunders, Philadelphia, p.379-381, 1990. 5. B挀琀ker RO, Spadaro JA : Treatment of orthopaedic infections with electrically generated silver ions. J Bone Joint Surg 60A:871-881, 1978. 6. B挀rger TJ, Spadaro JA, Chapin SE, B挀琀ker RO : Electrically generated silver ions: Quantitative effects of bact挀rial and mammalian cells. Antimicrob Agents Chemother 9:357-358, 1976. 7. Boone DC : Applications of Iontophoresis. In: Electrotherapy. Wolf SL (Ed). Churchill Livingstone, New York, p.99-121, 1981. 8. Barranco SD, Spadaro JA, B挀rger TJ, B挀琀ker RO : In vitro effect of weak indirect current on staphylococcusaureus. Clin Orthop 100:250-255, 1974. 9. Brough KM, And挀rson DM, Love J, Overman PR : The effectiveness of iontophoresis in reducing d挀ntin hypers挀nsitivity. J Am Dent Assoc 111:761-765, 1985. 10. Chantraine A, Ludy JP, B挀rger D : Is cortisone iontophoresis possible ?. Arch Phys Med Rehabil 67:38-40, 1986. 11. Cornwall MW : Zinc iontophoresis to treat ischemic skin ulcers. Phys Ther 61:359-360, 1981. 12. Cummings J : Iontophoresis. In : Clinical Electrotherapy. Nelson RM & Currier DP (Ed). Appleton-Century-Crofts, East Norwalk, p.231-241, 1987. 13. Downer AH : Physical Therapy Procedures. 4th ed., Charles C Thomas, Springfield, pp.177-182, 1974. 14. Ganeshmoorthy J, Saravanapavananthan T : A case of hyperhidrosis successfully treated with 20 aluminium chloride hexahydrate in 95% ethyl alcohol. Singapore Med J 31:85-86, 1990. 15. Gangarosa LP Sr, Hill JM, Thompson BL, Leggett C, Risssing JP : Iontophoresis of vidarabine monophosphate for herpes orolabialis. J Infect Dis 154:930-934, 1986. 16. Gangarosa LP Sr, Payne LJ, Hayakawa K, McDanieal WJ, Davis RE, Thompson BM : Iontophoretic treatment of herpetic whitlow. Arch Phys Med Rehabil 70:336-340, 1989. 17. Greminger RF, Elliott RA, Rapperport A : Antibiotic iontophoresis for the management of burned ear chondritis. Plast Reconst Surg 66:356-360, 1980. 18. Hellier M, Boers P, Lambert GA : Regional ocular gentamicin levels after transcorneal and transscleral iontophoresis. Invest Ophthalmo Vis Sci 31:909-916, 1990. 19. Kahn J : Use of iontophoresis in Peyronie's diseas: A case report. Phys Ther 62:995-996, 1982. 20. Kellogg DL Jr, Johnson JM, Kosiba WA : Selective abolition of adrenergic vasoconstrictor responses in skin by local iontophoresis of bretylium. Am J Physiol 257:H1599-606, 1989. 21. Laffree JB, Vermeij P, Hulshof JH : The effect of iontophoresis of lignocaine in the treatment of tinnitus. Clin Otolaryngol 14:401-404, 1989. 22. Langley PL : Iontophoresis to aid in releasing tendon adhesion. Suggestion from the field. Phys Ther 64:1395, 1984. 23. Midtgaard K : A new device for the treatment of hyperhidrosis by iontophoresis. Br J Dermatol 114:485-488, 1986. 24. Nordenstrom BE, Eksborg S, Beving H : Electrochemical treatment of cancer. II : Effect of electrophoretic influence on adriamycin. Am J Clin Oncol 13:75-88, 1990. 25. Passali D, Bellussi L, Masieri S : Transtympanic iontophoresis. Laryngoscope 94:802-806, 1984. 26. Power Paper, Inc. Study No. 0067.08.83 (2006 May), No. 040415 (2204 April), No. 090315 (2003 September, No. 050320 (2003 May) 27. Power Paper, Inc. live demonstration, HBA high performance ingredient world congress (2003 April, New York) 28. Pratzel H, Dittrich P, Kukovetz W : Spontaneous and forced cutaneous absorption of indomethacin in pigs and humans. J Rheumatol 13:1122-1125, 1986. 29. Shen JL, Lin GS, Li WM : A new strategy of iontophoresis for hyperhidrosis. J Am Acad Dermatol 22:239-241, 1990. 30. Simmonds E, Alfaham M, Prosser R, Penney MD : Fractional measurements of sweat osmolality in patients with cystic fibrosis. Arch Dis Child 64:1717-1720, 1989. 31. Tannenbaum M : Iodine iontophoresis in reducing scar tissue. Phys Ther 60:792, 1980. 32. Wadsworth H, Chanmugam APP : Electrophysical Agents in Physiotherapy. 2nd ed., Science Press, Marrickville, p.182-198, 1983. 33. Watkins AL : A Manual of Electrotherapy. 2nd ed.,Lea & Febiger, Philadelphia, p.126-140, 1962. 34. White JW Jr : Treatment of primary hyperhidrosis. Mayo Clin Proc 61:951-956, 1986. 35. Wieder DL : Treatment of traumatic myositis ossificans with acetic acid iontophoresis. Phys Ther 72:133-137, 1992. 36. 服部一郞, 細川忠義, 和才嘉昭 : リハビリテ-ショソ技術全書. 醫學書院, 東京, p. 241-242, 1993. 37. 김두영, 전재복 : Iontophoresis를 이용한 수장족저 다한증의 치료. 대한피부과학회지 28:758-764, 1990. 38. 유창헌, 안경희, 나열설 : 이온삼투요법을 이용한 통증치료. 대한재활의학회지 14(1):35-39, 1990. 39. 정호중, 박인선 : Iontophoresis를 이용한 다발성 다한증의 치료 증례. 대한재활의학회지 15(2):123-127, 1991. 40. 황경상, 나은우, 조미래 : 이온삼투요법을 이용한 근골격계 질환의 치료에 관한 연구. 대한재활의학회지 16(1):88-93, 1992.

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