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BioSci 24237 BIOLOGICAL RHYTHMS AND SLEEP

BioSci 24237 BIOLOGICAL RHYTHMS AND SLEEP. CLASS #8 Circadian Control of Sleep-Wake Regulation January 30, 2003. The homeostatic regulation of sleep. Slow-wave activity (EEG power density in the 0.5-4 Hz range) is a marker of sleep intensity that is homeostatically regulated.

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BioSci 24237 BIOLOGICAL RHYTHMS AND SLEEP

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  1. BioSci 24237BIOLOGICAL RHYTHMS AND SLEEP CLASS #8 Circadian Control of Sleep-Wake Regulation January 30, 2003

  2. The homeostatic regulation of sleep Slow-wave activity (EEG power density in the 0.5-4 Hz range) is a marker of sleep intensity that is homeostatically regulated.

  3. Normal distribution of slow-wave activity (SWA) across a night of sleep Feinberg & Floyd, 1979.

  4. Rebound of SWA after total sleep deprivation Dijk DJ et al, 1990.

  5. Inhibition of SWA after a nap Dijk DJ

  6. Rebound of SWA after SWS deprivation Dijk DJ, 1987

  7. The circadian regulation of sleep 1. Evidence from studies of humans in temporal isolation (free-running conditions)

  8. Day synchronized free-running FREE-RUNNING RHYTHM OF BODY TEMPERATURE IN TEMPORAL ISOLATION Czeisler, C. A. (1986). Clock Time

  9. SLEEP DURING ENTRAINED AND FREE-RUNNING CONDITIONS Czeisler, Richardson, Coleman, Zimmerman, Moore-Ede, Dement & Weitzman (1981).

  10. average duration of sleep episodes (min ± SD) CIRCADIAN REGULATION OF SLEEP percent REM during sleep (mean ± SEM) percent of time asleep (mean ± SEM) core body temperature (°C) (mean ± SEM) Czeisler, Zimmerman, Ronda, Moore-Ede & Weitzman (1980). circadian phase(degrees) Approximate clock time 6 am 6 pm

  11. CIRCADIAN REGULATION OF SLEEP Czeisler, C. A. (1986).

  12. The circadian regulation of the sleep-wake cycle 2. Evidence from studies of extended wakefulness

  13. Circadian control of sleepiness and mood across 36 hours of continuous wakefulness Van Cauter E & Turek FW, 2001.

  14. 36-h constant routine conditions

  15. The circadian regulation of the sleep-wake cycle 3. Evidence from studies using ultra short sleep-wake cycles

  16. 90-min sleep-wake cycle Dantz B, Edgar DM, Dement WC, Electroencephal Clin Neurophysiol, 1994.

  17. Sleep propensity in the 7/13 sleep-wake schedule Lavie, P, 1996.

  18. The circadian regulation of the sleep-wake cycle 3. Evidence from “forced desynchrony” studies

  19. The 28-hour forced desynchrony protocol Dijk & Czeisler, Neuroscience Letters, 1994.

  20. Slow Wave Activity during the 28-hour forced desynchrony protocol Dijk & Czeisler, J Neurosci, 1995.

  21. Sleep architecture during forced desynchrony Dijk DJ, Monogr Clin Neurosci, 1997.

  22. Circadian modulation of sleep fragmentation plasma melatonin and body temperature during forced desynchrony Dijk et al, 1997.

  23. The circadian regulation of the sleep-wake cycle Lessons from studies of lesions of the SCN

  24. Lesion of the SCN abolishes sleep-wake cycle (rat) Edgar DM, 1994.

  25. Latency to sleep onset in intact and SCN-lesioned squirrel monkeys Edgar DM, 1994.

  26. Distribution of wakefulness in intact and SCN-lesioned squirrel monkeys Edgar DM, Dement WC, Fuller CA, J Neurosci 1993.

  27. The “opponent process” model Edgar DM, 1996.

  28. 3D plot of wakefulness within scheduled sleep episodes, circadian phase and time elapsed since start of sleep episode. Dijk & Czeisler, Neuroscience Letters, 1994.

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