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This study by S. Zhu et al. delves into the comprehensive characterization of induced pluripotent stem cell-derived hepatocytes (iMPC-Heps), shedding light on their functional properties, molecular signatures, and potential applications in regenerative medicine and drug discovery. The research outlines novel insights into the cellular behavior of iMPC-Heps, providing a foundation for understanding their therapeutic potential and challenges in liver disease. Through a combination of experimental and analytical approaches, the study offers valuable contributions to the field of liver cell biology and sets the stage for further advancements in the development of personalized medicine strategies.
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Characterization of iMPC-Heps. S Zhu et al. Nature 000, 1-5 (2014) doi:10.1038/nature13020