NIGMS Award: 1U54GM104944-01A1

1. Mountain West Research ConsortiumClinical Translational Research – Infrastructure NetworkThe Mountain West CTR-IN Robert D. Langer, MD, MPH Principal Investigator Research Professor of Allied Health Sciences, UNLV Associate Dean for Clinical and Translational Research and Professor of Family Medicine-Las Vegas, UNSOM NIGMS Award: 1U54GM104944-01A1

2. What is it? • $20 million 5 year NIH Grant under the IDeA Program • Involving 13 universities across the 7 IDeA states in the Mountain West Research Consortium

3. What are the 7 Mountain West states? Alaska Hawaii Idaho Montana Nevada New Mexico Wyoming

4. Support: to foster Clinical and Translational Research (CTR) according to NIH Definitions for Core Resources to facilitate the development of researchers moving into CTR BOOTSTRAP CTR ACROSS THE MOUNTAIN WEST

5. We will sink or swim based on the increase in “R-level” translational and clinical research that we achieve across the region over the next 4 years “a rising tide that … … lifts all ships.”

6. Who is in it? • UNLV [host] • UNR/UNSOM • U. Alaska – Anchorage • U. Alaska – Fairbanks • U. Hawaii – Manoa • Boise State U. • Idaho State U. • U. Idaho • Montana State U. • U. Montana • New Mexico State U. • U. New Mexico • U. Wyoming

7. What will it do? • Provide pilot grants of $40,000-$75,000/yr • Support Mini-Sabbatical and Visiting Scholar awards to build collaborations • Provide infrastructure and services through Key Component Activities

8. Funding preference • Promising Early Career or New Investigators developing clinical or translational research programs • Established Investigators moving from bench to translational or clinical • Projects focused on health issues relevant to the region, including those in rural and vulnerable populations

9. What will it do? • Use an NIH-style approach to applications and funding • Model the processes that clinical and translational investigators need to master to compete successfully for NIH support

10. Key Component Activities (KCAs) • Education, Mentoring & Career Development KCA • Study Design & Biostatistics KCA • Pilot Grant KCA • Administrative KCA, including editorial support, award management, Annual Meeting

11. Education Mentoring Study Design Biostat Annual Meeting ALL AVAILABLE regardless of whether you’ve received a competitive award from the CTR-IN

12. What will it do? • Hold an Annual Meeting to share science, motivate, build collaborations, & conduct study business that will: • rotate across the 13 partner institutions • feature an annual research theme relevant to health in the region • bring together supported investigators, interested researchers from the region, key administrators from partners, external scientists, the regional biostat team, and senior project staff First Annual Meeting at UNLV June 23 – 25, 2014 free registration, hotel rate ~ $100/night

13. What’s the current status? • Round 1 Pilot Grants: • 24 applications, 6 awarded • Round 1A Pilot Grants: • 63 applications, 14 awarded

14. Year 1 Pilot Grants

15. What’s the current status? • Round 2 Pilot Grant RFA for 7/1/14 – 6/30/15: • Letters of Intent with Abstacts were due 3/7/14 • 122 LOIs with Abstracts received • Invitations to submit 3/14/14 • Applications due 4/25/14 • Awards announced at Annual Meeting 6/25/14 • Earliest start date 7/1/14 • All information at: ctrin.unlv.edu

16. Letters of Intent for Year 2 Pilot Grants Total 122

17. Visiting Scholars • Call still open • Funds must be expended by 06/30/14 • 4 applications to-date, all awarded • U Montana – to PG Awardee • UNLV – to PG Awardee • U Hawaii • UNLV

18. PEOPLE!

19. Your First Call … Your Local Concierge http://ctrin.unlv.edu/?page_id=447

20. Senior Leadership • Administrative Core • Bob Langer, UNLV, PI • Jim Kenyon, UNR, Proj Coord. • Carl Reiber, UNLV, Assoc. Dir. • John Foreyt, UNSOM, Eval. Dir. • Pilot Grants • Curtis Noonan, UMT, Director • Bill Shuttleworth, UNM, Assoc. Dir. • Education & Mentoring • Jillian Inouye, UNLV, Directorer • Bruce Shiramizu, UH, Mentoring • Pope Moseley, UNM, Mentoring • Merle Kataoki-Yahiro, UH, Educ • Craig Molgaard, UMT, Educ • Design, Epidemiology, Biostat • Pope Moseley, Director UNM CTSA: Richard Larson

21. website ctrin.unlv.edu NIGMS Award: 1U54GM104944-01A1

22. Mountain West CTR-IN Organizational Structure Governance and Membership AFFILIATION COLOR CODE UNLV UNSOM U. New Mexico U. Montana NIH Other Institutions Steering Committee Robert Langer, MD, MPH, Principal Investigator Jim Kenyon, PhD, Project Coordinator, Partners John Foreyt, PhD, Project Coordinator, T&E Rafael Gorospe, MD, PhD, Project Officer Maria Canto, DDS, MS, MPH, Project Scientist Internal Advisory Committee Carolyn Yucha, PhD, Co-Chair Thomas Schwenk, MD, Co-Chair VPRs of all 13 Partner Universities Robert Langer, MD, MPH, PI, ex oficio Jim Kenyon, PhD, Project Coordinator, ex oficio External Advisory Committee 6 to 10 External Scientists from outside the 7 state region Principal Investigator Robert Langer, MD, MPH Executive Committee PI 2 Project Coordinators 3[4 with PI]KCADirectors Assoc. Director, Admin KCA Lead Liaison CTSC Coordinator Admin KCA Robert Langer, MD, MPH, KCA Director Carl Reiber, PhD, Assoc. Director Jim Kenyon, PhD, Project Coordinator Educ & Mentoring KCA Jillian Inouye, PhD, KCA Director Education Unit Mentoring Unit Concierges Jill Zimbelman, Lead Concierge Regional Network Track & Eval Unit John Foreyt, PhD, Project Coordinator UNM CTSC Richard Larson, MD, Coord. Pilot Grant KCA Curtis Noonan, PhD, KCA Director CRDEB KCA Pope Moseley, MD, KCA Director Regional Biostatistician Network