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RNA Structures. September 19, 21 2006. Ribose ring. A form conformation. RNA conformation angles. UpA. UpA. UpA. UpA. GpC. RNA oligonucleotide A form. Crystal vs solution conformation. Internal loopin xtal Full loop in solution. Schematic of internal loop. Water involved in mispair.
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RNA Structures September 19, 21 2006
Crystal vs solution conformation • Internal loopin xtal • Full loop in solution
Ribozymes • RNA with catalytic activity
References “The Crystal Structure of an All-RNA Hammerhead Ribozyme: A Proposed Mechanism for RNA Catalytic Cleavage.” Cell, Vol. 81, June 30, 1995, pp. 992-993, 995. “Crystal Structure of an RNA double helix incorporating a track of non-Watson-Crick base pairs”, Nature, Vol. 353, October 10, 1991, pp. 579, 581. Leontis and Westhof. RNA, Vol. 7, 2001, pp. 499-512 Neidle, Stephen. Nucleic Acid Structure and Recognition. Oxford University Press, 2002, pp. 140-142, 148. Neidle, Stephen, ed. Oxford Handbook of Nucleic Acid Structures. Oxford University Press, 1999, p. 610. Saenger, Wolfram. Principles of Nucleic Acid Structure. Springer-Verlag New York Inc., 1984, pp. 251, 332-333, 335.