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Nucleotides and Amino Acids

Nucleotides and Amino Acids. PR 613 Structural Biology I Dr. Eric Wickstrom. Structure dictates function. Nucleic Acids. Triple helix. Southern Northern. Catalytic RNA. Antiparallel B-form (Southern) double helix.

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Nucleotides and Amino Acids

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  1. Nucleotides and Amino Acids PR 613 Structural Biology I Dr. Eric Wickstrom

  2. Structure dictates function

  3. Nucleic Acids Triple helix Southern Northern

  4. Catalytic RNA

  5. Antiparallel B-form (Southern) double helix Ring stacking and hydrophobic repulsion stabilize helix. Hydrogen bonds permit close approach, but don’t add stability!

  6. Dynein TcTex1

  7. C to N, over the bridge Sidechain on the left in an L-amino acid

  8. Aromatic (p-orbital) amino acids

  9. pK 10.5 pK 4 pK 4 pK 8

  10. pK 10.5 pK 12.5 pK 6

  11. Sperm whale myoglobin a-helix 3.6 aa/turn 5.4 Å/turn 1.5 Å/aa 8 a-helices

  12. Prealbumin b-sheet 2.0 aa/turn 7 Å/turn 3.5 Å/aa 16 b-sheets

  13. b-turns

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