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1. Hemodynamic Disorders, Thromboembolic Disease, and Shock
OBJECTIVES
Edema
Hyperemia and Congestion
Hemorrhage
Hemostasis and Thrombosis
Embolism
Infarction
Shock
3. Hyperemia
Usually physiologic rather than in pathologic (inflammatory) conditions
Congestion
Causes
Consequences
Tissue Hypoxia ?Degeneration ? Scarring/Fibrosis ( Cardiac Cirrhosis in Liver)
Capillary rupture ? Focal small hemorrhages ?Hemosiderin laden macrophages (Heart Failure Cells in Lung)
Organ systems involved = Lung, Liver
Lungs ? Acute ( Engorged Pulmonary capillaries, alveolar hemorrhages,) Chronic (thickened fibrous septa, Heart failure cells)
Liver ? Acute (distended central hepatic veins, centrilobular hepatocyte degeneration), Chronic ( Nut Meg liver, fibrosis – Cardiac cirrhosis, centrilobular necrosis)
4. Hyperemia and Congestion
5. Liver - congestion