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What links these pictures?

What links these pictures?. the science teacher.co.uk. Nadrolone. S cientists will conduct 5,000 urine and 1,000 blood tests at the Games – the most comprehensive testing programme at any Olympics – and Professor Cowan said he expected less than 50 positive tests.

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What links these pictures?

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  1. What links these pictures? the science teacher.co.uk

  2. Nadrolone Scientists will conduct 5,000 urine and 1,000 blood tests at the Games – the most comprehensive testing programme at any Olympics – and Professor Cowan said he expected less than 50 positive tests.

  3. Using Mass Spectrometry to identify banned substances in sport 28/03/12 Learning goals: Identify simple organic compounds that have identical masses by interpreting their mass spectra. To be able to work as a group to solve a problem by selecting appropriate resources. 1. Understand the basic principles of how a mass spectrometer works and interpret output data from a mass spectrometer 2. Describe some uses of mass spectrometers

  4. Mass spectrometry

  5. What do we know already? Annotate your picture in groups to show the main stages that take place in the mass spectrometer. Write an equation to show what happens when substance X is put into the spectrometer Identify substance A and B from the spectra Label your diagram to show the path of an ion with a large mass to charge ratio through the spectrometer Draw on your diagram to show the path of an ion with a small mass to charge ratio as it moves through the spectrometer What questions do you still have?

  6. unknown substance A (m/z)

  7. THE OUTPUT What is the relative molecular mass of this molecule?

  8. Fragmentation of organic molecules

  9. Ethanol Key terms: Relative intensity (%) m/z

  10. These two molecules are formed within the body from the breakdown of an anabolic steroid called BGT. They both have the same relative molecular mass. How would you be able to use mass spectrometry on a urine sample to determine if athlete MC2 had consumed BGT before the race? H A. H B. H H O H C H C C H C C C H H O H H H MC2

  11. H A. H B. H H O H C H C C H C C C H H O H H H How can we distinguish between these molecules using mass spectrometry? 1. For each molecule draw a spectrum showing the fragments formed. Start with the molecular ion peak. Assume equal intensity for each peak unless you can explain why? HELP AT THE BACK. Ext: write equations to show the formation of each fragment. 2. If you isolated substance A and B, what chemical tests could you do to distinguish them. Include equations in your answer and name substances.

  12. Molecule A Relative intensity (%) 60 50 55 m/z

  13. H H Molecule B O H C C C H H H Relative intensity (%) 60 50 55 m/z

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