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Welcome!. Esophageal Health, Acid Reflux, Barrett’s and Cancer Philip N Styne, MD AGAF Medical Director Digestive Health Center. Upper GI tract. Function of upper GI anatomy. Esophagus - passes food and fluid from mouth to stomach Stomach - mechanical and enzymatic digestion.
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Welcome! • Esophageal Health, • Acid Reflux, Barrett’s and Cancer • Philip N Styne, MD AGAF • Medical Director • Digestive Health Center
Function of upper GI anatomy • Esophagus - passes food and fluid from mouth to stomach • Stomach - mechanical and enzymatic digestion
Function of upper GI anatomy • Pancreas & liver - digestive enzymes and detergents • Small intestine - absorbs salts, vitamins, minerals and food
Gastroesophageal Reflux • Abnormal return of food, fluid, acid and digestive enzymes into the esophagus.
Gastroesophageal Reflux • Acid has both digestive and protective role • Lining of the esophagus does not make acid, has no barrier to acid exposure • Lining of stomach makes acid and has its own acid barrier
Gastroesophageal Reflux • Esophagogastric junction three-part system to control reflux of gastric contents into the esophagus
Gastroesophageal Reflux • Reflux results in: • Heartburn • Inflammation • Stricture • Barrett’s Esophagus • Asthma, cough, throat clearing and hoarseness
Lifestyle Changes • Nutrition • What, when & how much? • Diets consisting mainly of green and yellow vegetables • Small meals • Nothing to eat for 3 hours before bedtime
Lifestyle Changes • Diet • Maintaining a healthy weight • Low fat meals • Limited alcohol • No tobacco products
Lifestyle Changes • Walking after evening meal for 20 minutes • Elevation of the head of the bed
Medication • Acid reduction reduces symptoms and esophageal inflammation • Antacids • H2RA • PPI • Prokinetics
Barrett’s Esophagus • Result of reflux • Precursor of Esophageal Cancer • Predictable changes before Cancer • Treatable with endoscopic procedure
Barrett’s Esophagus • Due to chronic reflux: • Risk of cancer • Adenocarcinoma which is associated with Barrett’s is the fastest increasing gastrointestinal cancer.
Esophageal Cancer • Fastest rising rate of all gastrointestinal cancers. • The cancer associated with Barrett’s Esophagus has increased over 400%.
Our Goal: • Prevent cancer morbidity and mortality. • Reduce occurrence and find earlier more curable stage.
Endoscopy • Allows evaluation of the lining of the upper-intestinal tract • Allows for biopsy of the esophagus
Endoscopy Acid Reflux Normal Esophagus Barrett’s Esophagus Esophageal Cancer
Ulcers & Itis • Barrier breakers result in inflammation of stomach and duodenum including ulcers • ASA\NSAID\Cox 2 inhibitor have the ability to affect gastric acid barrier • Helicobacter pylori
Ulcers & Itis • Small intestine disease • Celiac sprue, gluten sensitivity • Lactose intolerance • Other carbohydrate malabsorption • Giardia • Bacterial overgrowth
Questions? For more information visit: www.FHDigestive.com Information sheets and priority appointments available.