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p=0.023. n.s. n.s. A. BDCA2. CD11c. IL-3R. CD80. CD86. pDCs. mDCs. B. CD81. SR-BI. CLDN1. DC-SIGN. pDCs. mDCs. C. Fig. 1, Lambotin et al. 10 7. 10 7. 10 6. 10 6. 10 5. 10 5. 10 4. 10 4. 10 3. 10 3. 10 2. 10 2. 10 1. 10 1. 10 0. 10 0. NC. NC. rat IgG. rat IgG.
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p=0.023 n.s. n.s. A BDCA2 CD11c IL-3R CD80 CD86 pDCs mDCs B CD81 SR-BI CLDN1 DC-SIGN pDCs mDCs C Fig. 1, Lambotin et al.
107 107 106 106 105 105 104 104 103 103 102 102 101 101 100 100 NC NC rat IgG rat IgG PBS PBS Anti-SR-BI Anti-SR-BI Anti-CD81 Anti-CD81 mouse IgG mouse IgG Anti-DC-SIGN Anti-DC-SIGN Anti-CLDN1 Anti-CLDN1 B C NC + HCVcc overlay Anti-E2 Anti-core pDCs pDCs mDCs mDCs pDCs mDCs p = 0.012 100 100 120 100 80 80 80 60 60 % inhibition of HCVcc utpake % inhibition of HCVcc utpake 60 40 40 40 20 20 20 0 0 0 pDCs mDCs Anti-HCV Anti-HCV Anti-SR-BI Anti-SR-BI Anti-CD81 Anti-CD81 Anti-CLDN1 Anti-CLDN1 A pDCs mDCs Copies HCV RNA/ µg cellular RNA Copies HCV RNA/ µg cellular RNA D E number of E2 positive cells/ total number of cells (n=300) Fig. 2, Lambotin et al.
HCV E2 HCV E2 Rab5 Rab5 Overlay Overlay HCV E2 HCV E2 Lamp1 Lamp1 Overlay Overlay HCV E2 HCV E2 CD71 CD71 Overlay Overlay pDCs mDCs A B CD71 MHC I Overlay Lamp1 MHC I Overlay CD71 MHC II Overlay Lamp1 MHC II Overlay Fig. 3, Lambotin et al.