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展开理想的翅膀 让梦想照进现实

展开理想的翅膀 让梦想照进现实. Sidong Xiong, Ph.D. 0512-65113488 immfd@126.com. Oct 26, 2011 Suzhou, China. 故 事 缘 起. 1981~1984 （卫生防疫站， CDC ） ？？ 乙型肝炎 ？？ 子宫颈癌. 故 事 展 开. 1984 年 师从著名的微生物学家 王言贵 教授 乙型肝炎发病机制的研究 乙型肝炎的动物模型 土拨鼠（ woodchuck 、 groundhog ）模型. 另 辟 蹊 径.

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展开理想的翅膀 让梦想照进现实

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  1. 展开理想的翅膀 让梦想照进现实 Sidong Xiong, Ph.D. 0512-65113488 immfd@126.com Oct 26, 2011 Suzhou, China

  2. 故 事 缘 起 1981~1984（卫生防疫站，CDC） ？？ 乙型肝炎 ？？ 子宫颈癌

  3. 故 事 展 开 1984年 师从著名的微生物学家 王言贵 教授 乙型肝炎发病机制的研究 乙型肝炎的动物模型 土拨鼠（woodchuck、groundhog）模型

  4. 另辟蹊径 1985年 中国医学科学院（协和医科大学）林玉纯 教授 德国癌症研究中心 Harald zur Hausen 子宫颈癌病毒病因学研究 Papilomavirus Multiple genotypes（warts, cervical cancer） Antibody-based genotyping

  5. 另辟蹊径 子宫颈癌病毒病因学研究 Viral genome specific antibody genotyping cancer high risk viral genotype DNA without immunnogenecity (Unable to induce antibody production)

  6. 另辟蹊径 子宫颈癌病毒病因学研究 Molecular Epidemiology study A new genotype of HPV was found in China

  7. 深 径 探 幽 HumanPapilomavirus Warts ？ Cervical cancer ？ Mechanisms Virus Host

  8. 深 径 探 幽 1989 师从 著名的免疫学家 林飞卿 教授 抗病毒免疫的细胞与分子机制

  9. 老树新花 HBV： WORLDWIDE HEALTH PROBLEM WORLD 350 MILLION PEOPLE INFECTED 240 MILLION ETHNICALLY CHINESE 1 MILLION DEATHS ANNUALLY 400 MILLION BY THE YEAR 2000 CHINA 130 MILLION INFECTED POPULATION 10% CHRONIC CARRIERS

  10. 老树新花 1990 师从著名的病毒学家 闻玉梅 院士 乙肝病毒感染慢性化机制及防治策略研究

  11. Anti-HBs ACUTE HEPATITIS B CTL Anti-HBc HBV DNA HBsAg Anti-HBe HBeAg ALT 0 4 8 12 16 20 24 (W) CHRONIC HEPATITIS B ALT HBV DNA HBsAg HBeAg Anti-HBc Anti-HBe 0 1 2 3 4 5 6 (M) 1 2 3 4 5 6 7 8 9 10 (Y)

  12. Anti-HBs seroconversion after vaccination with conventional protein HBV vaccine

  13. IMMUNE TOLERANCE • HBV PERSISTENT INFECTION • NO SPECIFIC IMMUNORESPONSE HBV

  14. DHBV IMMUNITY TO DHBV VIRAL INFECTION

  15. DHBV D1 DUCKLING DHBV ANTIGENS DHBV DNA STAPHYL. AU E. COLI DHBSAG DHBCAG ANTIBODY RESPONSE NO IMMUNITY TO DHBV VIRAL PERSISTENCE

  16. An immunotolerant duck model for DHBV Viral persistence for lifetime Undetectable both humoral and cellular immune response against DHBV Active immunization with natural structure of viral protein failed to abrogate immune tolerance

  17. Anti-HBs seroconversion after vaccination with conventional protein HBV vaccine

  18. DHBsAg SPA ANTI-DHBs SOLID MATRIX ANTIBODY ANTIGEN COMPLEX （SMAA）

  19. Ag: DHBsAg Ab: Anti-DHs One molecule harboring both antigen and antibody

  20. 待续 转第二部分

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