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Neuropsykologiske test Test-retest stabilitet og reliabilitet. Anders Gade. Gade. S-81 data. 20 personer retestet efter 3 måneder. Erik Lykke Mortensen. Hanne Udesen. Gade. AGENDA-projekt. 77 personer retestet efter 4 uger (38 efter 10 mg escitalopram dgl; 39 placebo). Ulla Knorr

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  1. Neuropsykologiske test Test-retest stabilitetog reliabilitet Anders Gade Gade

  2. S-81 data 20 personer retestetefter 3 måneder Erik Lykke Mortensen Hanne Udesen Gade

  3. AGENDA-projekt 77 personer retestetefter 4 uger (38 efter 10 mg escitalopram dgl; 39 placebo) Ulla Knorr .. & Helena Dysgaard, Vibe Bredsdorf & Peter Kristian Jacobsen Gade

  4. ACD-gruppen (Agenda-Cimbi-Depad) HeleneCarstensenandVibe Bredsdorff(primarilyAgenda (with Peter KristianJacobsen)) GryZornhagen(Cimbi) and Eva Meldal(all 3) Sofie Folke Kasper Eskelund (primarily Depad together Julie Nyvang) Gade

  5. FReJA – prospektiv neuropsykologiskundersøgelse 2002, 2005, 2010 Gade

  6. FReJA – prospektiv neuropsykologiskundersøgelse 2002, 2005, 2010 Tom Teasdale Korrelationer: 2002-2005 2002-2010 2005-2010 N: 38 31 35 (Indtil videre ikke renset for genbærere) 2002 gennemsnit: alder 53; uddannelsesscore 11.8; DART 28) Gade

  7. Test-retest reliabilitet Reliabilitet handler grundlæggende om målefejl ”A given score is thought to consist of two parts:the true score and the error. The true score is the actual value of a given individual on the constructif it were to measured completely accurately by the test. The error is the value of the extraneous influences on the measurement process”. Franzen, 1989, p.15 Gade

  8. Hvad skal vi kræve i test-retest korrelationskoefficienter? ”At MATRICS consensus meetings, high test-retest reliability was considered the most important test feature in a clinical trial”. ”The committee considered an r value of 0.70 to be acceptable fortest-retest reliability for clinical trials”. Nuechterlein et al., 2008 Gade

  9. Hvad skal vi kræve i test-retest korrelationskoefficienter? We here present findings from three new studies to show that (a) the BPP has a satisfactory Test-Retest reliability, r = 0.77Teasdale et al., 2011 BPP som gruppeprøve ved alder 19.2 år WAIS med individuel administration 4 år senere BPP – full scale IQ korrelation: 0.82 Mortensen et al., 1990 Gade AG# a444a

  10. ”Basisbatteri” og S-81 – test-retest korrelationer i enkeltprøver og i ”faktorskorer” Domæne # test faktor r enkelttest mean rAbstraktion 2 .82 .60 Hukommelsesspændvidde 3 .89 .71 Verbal indlæring 3 .56 .47 Genkendelse 5 .87 .68 Visuomotorisk tempo 3 .56 .55 Visuo-spatiale prøver 4 .70 .41 PASAT 2 .51 .38 Visuel syntese 2 .80 .68 Total BB 13 .77 .51 Mean total af 7 faktorer 24 .90 .54 QS 50 ord SDMTvis.gestalter Gade

  11. Eksempel på brug af test-retest data: SDMT Test 1Test 2Pearson rSESt. difference 95% 45.3 48.8 .74 3.9 10.8 95% konfidensintervaller SkoreForbedringForværring +/- 7.6 + 14.3 - 7.3 Gade

  12. ”Reliable change index” Temkin et al. (1999). JINS, 5, 357-369Bird et al. (2003), Br.J.Clin.Psychol., 42, 407-425 Recognition Memory Words (QS 50 ord) 1. us.2. us.r London 46.1 46.5 .69 S-81 46.6 47.2 .70 Gade

  13. Test reliabilitet - Visuelle Gestalter Pearsonr Indlæring: .14 Retention: .27 Gade

  14. Gade

  15. Reys komplekse figur 3 og/eller 30 minutters retention? Begge er OK reliable ved 4 ugers retest: r = .80 / .85 Korrelation mellem præstation ved 3 og 30 min: .96 / .97 Gade

  16. NART / DART Moray House Test: 11 årNART: 79 år 45 demens: r= 0.60 464 NC: r= 0.63 McGurn et al. (2004), Neurology, 62, 1184-6#2197j / x105a Gade

  17. Danish Adult Reading Test Examples of items GAGE GIN MONTAGE ... NEUTRUM LANCERE POMERANS MARKIS KASEIN CLOU … HUGUENOT ECLAT OBSKUR Gade

  18. Danish Adult Reading Test Examples of items GAGE GIN MONTAGE ... NEUTRUM LANCERE POMERANS MARKIS KASEIN CLOU … HUGUENOT ECLAT OBSKUR Test-retest reliabilitet (AGENDA & FReJA) Alle (N: 77): 0.93 Placebo (N: 39): 0.93 2002-2005: 0.932002-2010: 0.92 2005-2010: 0.92 Gade

  19. Visuomotorisk tempo r S-81AGENDAFReJA • SDMT .74 .83 .89 / .90 / .94 • Trails A .43 .67 .67 / .58 / .47 • 3) Trails B .47 .68 .80 / .78 / .83 Faktorscore .56 .88 / .84 / .87 I faktorscore sammen med Rey og Blokmønstre: AGENDA .91

  20. Eksekutive tests ”Findings demonstrated modest reliability of individual EF measures but very high stability of a latent EF construct”. Ettenhofer et al., 2006 Gade

  21. Eksekutive tests - S-81 Sorteringsprøve r: .37 WCST, antal fejl i alt r: .45 Gade

  22. Eksekutive tests - AGENDA r alle placebo Ordmobilisering – S .48 .42 Ordmobilisering – dyr .69 .84 Bogstav-tal sekvensering .50 .57 Stroop inkongruente .81 .80 Eksekutive faktor .79 .84 Eksekutiv faktor i FReJA: .89 / .72 / .80 Gade

  23. Stroop - neutral XXX XXX XXX XXX XXX XXX XXX XXX XXX XXX XXX XXX Gade

  24. Stroop - kongruent blå grøn rød blå gul grøn gul blå gul rød grøn blå Gade

  25. Stroop - inkongruent gul rød blå gul grøn rød blå rød blå gul blå gul Gade

  26. Stroop subtraktion = Stroop inkongruent (sekunder)minus Stroop kongruent (sekunder) ”Test-retestreliability coefficients were high for standard … Stroop tasks when reliability was measured using response latencies alone. However, test-retest coefficients were unacceptably lowwhen reliability estimates were calculated using difference scores” Strauss et al., 2005(Stroop kongruent r .71; inkongruent .79; subtraktion .46) Stroop inkongruent r .81 / .80Stroop subtraktion r .65 / .60 Gade

  27. Grundig gennemgang af eksekutive tests senere ….. ? Fx på kvartalsmøde i 2012 Gade

  28. Konklusioner • Nogle af vore prøver – men ikke alle - har glimrende reliabilitet • 2. Brug viden om prøvernes reliabilitet i dinudvælgelse af prøver 3. Brug viden om prøvernes reliabilitet i dine konklusioner, så du ikke udtaler dig mere sikkert, end dine data berettiger til 4. Faktorskorer er generelt mere pålidelige end enkelttests. Hvis du bruger prøver med ringe reliabilitet – især hukommelse og eksekutive funktioner – så brug mere end én Gade

  29. Gade

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