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Multivalent “Artificial Antibody” Based on RNA/Dendrimer-Like Star Polymer Hybrid Nanomaterials

V L. V H. C L. C H1. V H2. V H3. Multivalent “Artificial Antibody” Based on RNA/Dendrimer-Like Star Polymer Hybrid Nanomaterials. Yong Wang, University of Connecticut, DMR 0705716.

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Multivalent “Artificial Antibody” Based on RNA/Dendrimer-Like Star Polymer Hybrid Nanomaterials

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  1. VL VH CL CH1 VH2 VH3 Multivalent “Artificial Antibody” Based on RNA/Dendrimer-Like Star Polymer Hybrid Nanomaterials Yong Wang, University of Connecticut, DMR 0705716 Antibodies have played critical roles in various biological and biomedical applications. However, antibodies have shortcomings that can significantly limit their effectiveness and efficiency in many of these applications. Thus, it is highly desirable to seek alternative bio-nanostructures, which can mimic antibody’s molecular recognition capability but have novel functions that natural antibodies do not possess. Our research is aimed at developing novel hybrid nanobiomaterials with nucleic acid aptamers and dendritic polymers. This research will deliver effective “artificial antibodies” with unique properties. For instance, we have used temperature-responsive aptamers to create novel synthetic antibody-like nanostructures with the capability of reversible cell binding that natural antibodies do not possess (Figure 1). The acquired knowledge can help us to design future biomimetic nanomaterials with superb functionality and expand their applications in many fields such as drug delivery, bioimaging, and cell separation. Representative papers acknowledging this award: A B D C E cell binding reversible binding • Zhou J, Soontornworajit B, Martin J, Sullenger BA, Gilboa E, Wang Y. A hybrid DNA aptamer-dendrimer nanomaterial for targeted cell labeling.  Macromolecular Bioscience. 2009; 9: 831-835.   • Zhou J, Soontornworajit B, Wang Y. A temperature-responsive antibody-like nanostructure. Biomacromolecules. 2010; 11: 2087-2093. Figure 1. Nanostructures of natural antibodies (A: IgG; B: IgM) and artificial antibodies (C:bivalent; D: multivalent). E: Artificial antibody-mediated reversible cell binding.

  2. Multivalent “Artificial Antibody” Based on RNA/Dendrimer-Like Star Polymer Hybrid Nanomaterials Yong Wang, University of Connecticut, DMR 0705716 The research activities are closely integrated into diverse educational activities: ☺ Students at different levels, including graduates, undergraduates, and high school students have participated in every aspect of the proposed research; ☺Concepts of novel nanobiomaterials and nanomedicines have been introduced in Drug Delivery and Polymeric Materials courses; ☺ High school teachers and students have been educated through numerous outreach programs including da Vinci Project, E2K Program, and UConn Mentor Connection, Upward Bound /ConnCAP Program. Based on the training, the participating K-12 students have acquired hands-on nanobiotechnology research experience and a better understanding of the nature of biomaterials and bioengineering. Pictures of high school students receiving the training of synthesizing and characterizing nanoconjugates and nanostructured hydrogels.

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