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The case of the “wondering” goat 07-1932

The case of the “wondering” goat 07-1932. Ronald D. Tyler Jr.* Geoff Saunders* Bernard Jortner* Dan Righter † James Mandell ‡ Gerald Campbell § * Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, VA † Washington Animal Disease Diagnostic Laboratory, Pullman, WA

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The case of the “wondering” goat 07-1932

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  1. The case of the “wondering” goat07-1932 Ronald D. Tyler Jr.* Geoff Saunders* Bernard Jortner* Dan Righter† James Mandell‡ Gerald Campbell§ * Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, VA † Washington Animal Disease Diagnostic Laboratory, Pullman, WA ‡University of Virginia Medical Center, Charlottesville, VA §University of Texas Medical Center, Galveston, TX Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  2. Signalment • “Streak” • 11-year-old Alpine-Toggenburg cross wether Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  3. History • Goat has been “wondering” in pasture for past month. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  4. History - really • Goat has been “wandering” in pasture for past month & star gazing. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  5. Gross Pathology • During sectioning of the brain a well demarcated mass was discovered in the mid-brain extending to the rostral brainstem. • No gross lesions were initially noted at necropsy. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  6. Pineal gland http://upload.wikimedia.org/wikipedia/commons/6/6b/Illu_pituitary_pineal_glands.jpg Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  7. Histopathology:Brain: Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  8. Immunohistochemistry • Cytokeratin = Positive • GFAP = Negative • Synaptophysin = Positive • S-100 = Positive • Neurofilament = Negative • βIII-tubulin (mAb TUJ1) = Pending • S-Antigen = Pending Synaptophysin IHC Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  9. Immunohistochemical profiles: Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  10. Distinguishing features Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  11. Rosettes Homer-Wright rosettes:Supratentorial PNET (Neuroblastoma) Pineocytomatous rosettes:Pineocytoma Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  12. Electron Microscopy Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  13. Case Summary • Differential Diagnoses: • Pineocytoma • PNET (Neuroblastoma) Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  14. References • Maxie MG, Youssef S: Neoplastic Diseases of the Nervous System. In: Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals, ed. Maxie MG, 5th ed., v1., pp.450-451, Elsevier-Mosby, St. Louis, MO, 2007 • Koestner A, Higgins RJ: Tumors of the Nervous System. In: Tumors in Domestic Animals, ed. Mueten DJ, 4th ed., pp.319-340, Iowa State Press, IA 2002 • Summers BA, Cummings JF, DeLahunta A: Tumors of the central nervous system. In: Veterinary Neuropathology, ed. Summers BA, Cummings JF, DeLahunta A., pp.351-394, Mosby, St. Louis, MO, 1995 • Dario A, Cerati M, Taborelli M, Finzi G, Pozzi M, Dorizzi A: Cytogenetic and ultrastructural study of a pineocytoma, case report. Journal of Neuro-Oncology v48: pp.131-134, 2000. • Fevre-Montange M, Jouvet A, Privat K, Korf HW, Champier J, Reboul A, Auera M, Mottolese C: Immunohistochemical, ultrastructural, biochemical and in vitro studies of a pineocytoma. Acta Neuropathology. v95: pp.532-539, 1998. • Ellison D, Love S: Neoplasms. In: Neuropathology, ed. Ellison D, Love S, 2nd ed., pp.653-684, Mosby, St. Louis, MO, 2004 Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  15. Acknowledgments & Co-Authors • Special thanks to the many consultants on this case for lending there time and expertise. • Dr. Ronald D. Tyler Jr., Virginia Maryland Regional College of Veterinary Medicine, Anatomic Path Resident • Dr. Geoff Saunders, Virginia Maryland Regional College of Veterinary Medicine, Anatomic Pathologist • Dr. Bernard Jortner, Virginia Maryland Regional College of Veterinary Medicine, Anatomic Pathologist • Dr. Dan Righter, Washington Animal Disease Diagnostic Laboratory, Anatomic Path Resident • Dr. James Mandell, University of Virginia Medical Center, Department of Pathology, Human Neuropathologist • Dr. Gerald Campbell, University of Texas Medical Center, Department of Pathology, Human Neuropathologist Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  16. The End Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

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