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Thymus

Thymus. Thymus. Thymus. Primary lymphatic organ Anterior mediastinum Present – Infants – larger Adults – degenerated & infiltrated by adipose tissue. Thymus. Covered – Capsule - Dense irregular connective tissue Collagen fiber Elastic fibers with fibroblast

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Thymus

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  1. Thymus

  2. Thymus

  3. Thymus • Primary lymphatic organ • Anterior mediastinum • Present – • Infants – larger • Adults – degenerated & infiltrated by adipose tissue

  4. Thymus Covered – Capsule - • Dense irregular connective tissue • Collagen fiber • Elastic fibers with fibroblast • Septa (trabecula) • incomplete lobules

  5. Thymus Parenchyma • Epithelioreticular cells • Has lobules • Outer cortex • Inner medulla

  6. Thymus • Cortex • Thymocytes, • Macrophages, • Dispersed reticulo - epithelial cells.

  7. Medulla Stains lightly because lymphocytes are not densely packed Hassall’s corpuscle / thymic corpuscle

  8. Hassall’s corpuscle / thymic corpuscle • They are situated in the medulla of thymus. • It has a central core formed by degenerated epithelial cells surrounded by concentrically arranged epithelial cells. • These cells form a pink staining hyaline mass.

  9. Thymus Blood vessel Thymic lobule Interlobular septum Cortex Medulla Hassall’s corpuscle

  10. Hassall’s corpuscle Thymic lobule Medulla Cortex

  11. Blood thymus barrier • Blood vessels entering the thymus from the trabeculae get surrounded by the • sheath of connective tissue, • epitheliocyte

  12. Blood thymus barrier • Prevent most circulating antigens from leaving vasculature and entering the thymic cortex.

  13. Functions Of Thymus • Thymus act as a central organ of lymphatic system • It is essential in early weeks of neonatal life and regulates the growth of peripheral lymphoid tissue. • Thymus is enlarged in some autoimmune diseases(myasthenia gravis).

  14. PALATINE TONSIL

  15. PALATINE TONSIL

  16. PALATINE TONSIL • Present – oropharynx • Called diffuse lymphatic tissue Because lymphoid follicles – present just beneath lining epithelium.

  17. PALATINE TONSIL

  18. PALATINE TONSIL • Lined – stratified squamous non keratinized epithelium • Tonsillar crypts - epithelium dips – substance of tonsil • Lymphatic nodules with germinal center – present just beneath epithelium • There are • B & T lymphocytes • Mucous acini are seen

  19. Palatine tonsil Stratified squamous non-keratinized epithelium Lymphoid follicle Tonsillar crypt Mucous acini

  20. Palatine tonsil- magnified Stratified squamous non-keratinized epithelium Tonsillar crypt Mucous acini Lymphoid follicle

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