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Advanced Treatments in GI Disorders . Augustine J Lee, MD, FACS, FASCRS Colon and Rectal Surgery Fort Worth, Texas March 26,2011. Financial Disclosures. None. Goals of presentation. Multidisciplinary approach Advanced treatment options Standards of Care Optimal outcome Quality of Life
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Advanced Treatments in GI Disorders Augustine J Lee, MD, FACS, FASCRS Colon and Rectal Surgery Fort Worth, Texas March 26,2011
Financial Disclosures • None
Goals of presentation • Multidisciplinary approach • Advanced treatment options • Standards of Care • Optimal outcome • Quality of Life • Use of Technology
Case Presentation • Mr C.T. 55 year old man • Medical problems • Diabetes • High Cholesterol • Previous aortic valve replacement surgery • Financial auditor • Married, lives with wife
Case Presentation • Presented to HSW on June 2010 with these problems: • 3 weeks of bloating, constipation, anemia • Off and on rectal bleeding 8 years ago • Refused colonoscopy
Case Presentation • Physical Exam • No, HR 115, BP 160/80 • Appearing very uncomfortable • Markedly distended abdomen • Not tender
Case Presentation • Patient initially evaluated by gastroenterology team • Colonoscopy revealed mass in rectum with complete blockage • Biopsy proven cancer of the mid rectum
http://www.webmd.com/digestive-disorders/picture-of-the-colonhttp://www.webmd.com/digestive-disorders/picture-of-the-colon
Case Presentation • Large Intestinal Obstruction is surgical emergency • Decompress obstruction • Increased wall tension • Gangrene and perforation • Colostomy most common and safest procedure
Case Presentation • Colonic Stent • Alternative to emergency surgery and colostomy • Specialized technique • Interventional therapy
Case Presentation • Indications and Goals for Colonic Stents here…
Case Presentation • Over three days, Mr. CT began to improve • Bowel movements • Relief of pain and distention • Began to eat • Able to go home • Two weeks to recover
Step two • What to do with cancer? • How advanced is it? • Is it curable? • What is the best treatment possible?
Staging Colorectal cancer • Depends on 3 Things • Depth of Tumor • Involvement of Lymph Nodes • Distant Metastasis
Distant sites for Metastasis • Liver • Lung • Brain • Bone
Case Presentation • Staging for Mr. C.T. • CT scan • Liver – no evidence of mets • Lung - pneumonia, no evidence of mets • Enlarged lymph nodes visible • CEA level – 2.6
Case Presentation • Advanced Rectal Cancer • Presenting with Obstruction • Curable vs non-curable • “Neoadjuvant Therapy” • To Help or Prepare • Shrink and Downstage Tumor
Case Presentation • Oncology consultation • Radiation oncology • 5 weeks of one day weekly delivery of radiation • Chemotherapy • To help “sensitize tumor cells” • Makes radiation more effective
Case Presentation • 8 weeks after treatment stent fell out after BM one day • Patient no longer feeling full, or crampy, bowel movements near normal • Post neoadjuvantchemoradiation MRI
Case Presentation • Curative effort • Margins free of cancer • Sharp Total Mesorectal Surgery • Professor RJ Heald
TME “There is increasing evidence in the medical literature throughout the world that colorectal cancer is the most technique dependent of all the major malignancies. There is more difference in outcome in terms of cure, the number of permanent colostomies necessary, and in various other disabilities including impaired sexual function, than in any other cancer. The technique of total mesorectal excision (TME) for rectal cancer was developed by Professor Bill Heald in the early 1980s, and Basingstoke became the natural teaching centre for this precise surgical technique. The first Basingstoke Rectal Cancer Symposium was held in 1996 and is now an annual event, held during the last week of September.”
Sharp Excision • Mesorectal Envelope
Robotic Surgery • Enhanced visualization • Precision cautery, retraction • Minimally invasive method of precision surgery • Facilitates Nerve Sparing
Conclusion • Goals of advanced therapies in GI cancers • Increase chances of cure whenever possible • Improve quality of life after treatment • Minimally invasive techniques • Precision surgery • Preserve normal anatomic and physiologic function