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Critical Review of HIV Surveillance System in India

Critical Review of HIV Surveillance System in India . D.C.S. Reddy NPO, WHO-India. Evolution. 1985: Sero diagnostic facilities established 1986: First case & expansion of Dx. facilities 1992: HIV Sentinel surveillance (HSS) in AN & STD clinics

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Critical Review of HIV Surveillance System in India

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  1. Critical Review of HIV Surveillance System in India D.C.S. Reddy NPO, WHO-India

  2. Evolution • 1985: Sero diagnostic facilities established • 1986: First case & expansion of Dx. facilities • 1992: HIV Sentinel surveillance (HSS) in AN & STD clinics • 1998: Expansion of HSS and regular HIV estimation • 2001: Nation wide BSS and Mapping of MARPS • 2003: Expansion of HSS among MARPS

  3. Components of current HIV surveillance system in India • Surveillance among MARPS : (405 sites in 2007) • STD Clinic attendees (252 sites in 2007); FSW (83); MSM (18); IDU (30); Long Distance Truckers & Migrants (15 & 6) • General Population: • ANC attendees (628 sites) • National Behavioural Surveillance (2001 & 06) • AIDS Case & death Reporting • STI Surveillance

  4. Need for Review of Surveillance: Some concerns • Implementation of surveillance among MARPS through NGOs implementing TIs: • Conflict of interest & selection bias • Inadequate coverage • UAT sans consent in TI sites: An ethical dilemma • Relevance of HIV surveillance among STD patients (double counting?) • Sample size in ANC is 400: Is it sufficient? • Reporting of AIDS and STI cases: Clinic based, incomplete and delayed

  5. Need for Review of Surveillance: Some New Developments • Need to inform planning at district level under NACP-3 • Adequacy of data emerging from PMTCT, PITC & ART to supplement surveillance? • Suitability & Feasibility of new surveillance strategies (IBBS) & lab technologies (DBS & BED assay) to strengthen surveillance?

  6. Objecttives of review To recommend feasible and appropriate measures for improvement

  7. The Review: A Three Step Process • Step I: Small group meetings • Step II: Preparation of background documents • Step III: International consultation

  8. Step I: Small group meetings • To articulate key questions • Participants: Those who were closely associated with: • Implementation of surveillance • Surveillance data analysis • Separate meeting for each component

  9. Step II: Background Documents • Critical appraisal of current status • Prepared by experts associated with surveillance in India using – personal experiences • Literature review • Review of monitoring reports of prev. yrs. • Data from other relevant sources • Data analysis where needed and feasible (eg. Comparison of ANC surveillance & PMTCT data) • Circulated to proposed participants in the consultation

  10. Step III: International Consultation • Consensus based recommendations • In depth group discussions • Plenary • Participants: • NACO /WHO /UN partners (UNAIDS, UNICEF, UNFPA) /CDC /FHI /BMGF /National Institutes (ICMR & NIHFW)

  11. Group discussion during Consultation Five working groups deliberated on: • HIV surveillance among MARPS (STD pts., FSW, MSM, IDU, Migrants & L D Truckers) & BSS • HIV Surveillance in general population • STI surveillance • AIDS case surveillance • Laboratory issues related to surveillance

  12. Key questions about HIV surveillance among populations with high risk behaviors • Is UAT strategy in MARPS ethically acceptable? • How to ensure geographical coverage of HSS among MARPS? • What are the biases in MARP Surveillance? • What are the alternatives to overcome the issues of representation and bias & how to operationalize them? • Should surveillance be established among prisoners? • Does surveillance among STI patients add value in monitoring HIV trends in MARPS? • If not, is it time to phase out HIV surveillance in STI patients?

  13. Recommendations for HIV surveillance among MARPS • Concentrated epidemic in India: MARP Surveillance critical • Periodic MARP Mapping & size estimation • Replace BSS with scaled down IBBS (-lite) model with sufficient ext. validity every 2-3 years • Switch to UAT with consent • Switch to DBS for HIV testing after feasibility testing • Discontinue HIV surveillance in STI clinic sites in High Prev. states & phase out in Low Prev. states • Use subgroup analysis of ICTC data for HR behaviour popn. to identify emerging epidemics

  14. Significant outcomes accepted by NACO • Use of DBS and UAT with consent in MARP surveillance studied and being used • Fresh mapping completed & being validated • Accepted to phase out HSS among STD patients and to do subgroup analysis of VCTC data for MARPS to identify emerging infection • Protocol under preparation for IBBA (-lite) as recommended

  15. Significant outcomes accepted by NACO • protocol under preparation for piloting HIV case reporting using WHO case definitions • Agreed to strengthen STI surveillance – protocol to be prepared • BED Assay: Efforts to develop correction factor for subtype C and Avidity assay are underway at National AIDS Research Institute. Implementation depends on study outcomes

  16. Conclusions • Evaluation of HSS is possible by structured review and consultation • Helps in decisions in consensus with programme managers • Involvement of NACs leads to ownership of decisions and facilitates acceptance and implementation

  17. Thank You

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