1 / 11

UKCHIC Richard Gilson on behalf of the Hepatitis Subgroup Progress update July 2010

UK CHIC. UKCHIC Richard Gilson on behalf of the Hepatitis Subgroup Progress update July 2010. UK CHIC. Hepatitis subgroup. Main focus – HBV/HCV co-infection Data available Liver function tests HBV/HCV serology HBV/HCV viral load HBV treatment if this is a HAART component

steel-rivas
Download Presentation

UKCHIC Richard Gilson on behalf of the Hepatitis Subgroup Progress update July 2010

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. UKCHIC UKCHIC Richard Gilson on behalf of the Hepatitis Subgroup Progress update July 2010

  2. UKCHIC Hepatitis subgroup Main focus – HBV/HCV co-infection Data available • Liver function tests • HBV/HCV serology • HBV/HCV viral load • HBV treatment if this is a HAART component • Limited cause of death data

  3. UKCHIC What have we done already • HCV testing, prevalence, and impact on HAART outcome (Published Jo Turner et al – JVH advance online) • How can ALT flares best be defined (Published Loveleen Bansi et al – JAIDS)

  4. UKCHIC Research questions • What is the effect of hepatitis co-infection on HAART outcomes • immunological and virological response • drug toxicity • rate of treatment discontinuation • response to more potent therapies? • What is the impact of hepatitis co-infection on mortality and is this related to for eg. genotype? • What is the impact of acute HCV infection on the progression of HIV disease and response to HAART? • What are the associations between HCV co-infection, ALT/AST levels and lipid profiles? • Does HBV treatment have an impact on HIV resistance development? • Who requires a liver transplant and what is the outcome?

  5. UKCHIC Challenges – additional data • Options • Add data items to routine UK CHIC data download • Set up bespoke data collection • Additional data items • AFP • HCV/HBV genotype • Resistance data – link with Resistance Database • HBV/HCV treatment history • Other drugs – eg EPO/GCSF/TB Rx • Clinical – liver disease; alcohol • Other investigations – USS; liver biopsy; Fibroscan

  6. UKCHIC Plan • Agree data items • Additional data collection – funding application • Add data items to next data download • Continue analyses with available data

  7. UKCHIC Research questions • What is the effect of hepatitis co-infection on HAART outcomes • immunological and virological response • drug toxicity • rate of treatment discontinuation • response to more potent therapies? • What is the impact of hepatitis co-infection on mortality and is this related to for eg. genotype? • What is the impact of acute HCV infection on the progression of HIV disease and response to HAART? • What are the associations between HCV co-infection, ALT/AST levels and lipid profiles? • Does HBV treatment have an impact on HIV resistance development? • Who requires a liver transplant and what is the outcome?

  8. UKCHIC Research questions • What is the effect of hepatitis co-infection on HAART outcomes • immunological and virological response • drug toxicity • rate of treatment discontinuation • response to more potent therapies? • What is the impact of hepatitis co-infection on mortality and is this related to for eg. genotype? • What is the impact of acute HCV infection on the progression of HIV disease and response to HAART? • What are the associations between HCV co-infection, ALT/AST levels and lipid profiles? • Does HBV treatment have an impact on HIV resistance development? • Who requires a liver transplant and what is the outcome?

  9. UKCHIC Research questions • What is the effect of hepatitis co-infection on HAART outcomes • immunological and virological response • drug toxicity • rate of treatment discontinuation • response to more potent therapies? • What is the impact of hepatitis co-infection on mortality and is this related to for eg. genotype? • What is the impact of acute HCV infection on the progression of HIV disease and response to HAART? • What are the associations between HCV co-infection, ALT/AST levels and lipid profiles? • Does HBV treatment have an impact on HIV resistance development? • Who requires a liver transplant and what is the outcome?

  10. UKCHIC Research questions • What is the effect of hepatitis co-infection on HAART outcomes • immunological and virological response • drug toxicity • rate of treatment discontinuation • response to more potent therapies? • What is the impact of hepatitis co-infection on mortality and is this related to for eg. genotype? • What is the impact of acute HCV infection on the progression of HIV disease and response to HAART? • What are the associations between HCV co-infection, ALT/AST levels and lipid profiles? • Does HBV treatment have an impact on HIV resistance development? • Who requires a liver transplant and what is the outcome?

  11. UKCHIC Hepatitis subgroup Membership Caroline Sabin Sanjay Bhagani Loveleen Bansi Andrew Burroughs Teresa Hill Janice Main Mark Nelson Martin Fisher Alison Rodger Richard Gilson Chris Taylor

More Related