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Existing knowledge can prevent…. Waste Errors Poor quality clinical care Poor patient experience Adoption of interventions of low value Failure to adopt interventions of high value
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Existing knowledge can prevent… Waste Errors Poor quality clinical care Poor patient experience Adoption of interventions of low value Failure to adopt interventions of high value Source: Sir Muir Gray, Chief Knowledge Officer of Britain’s National Health Service. Quoted on http://www.nks.nhs.uk/.
Learning Objectives • At the end of the presentation, learners will: • be able to define evidence based medicine (also referred to as evidence based practice, evidence based eye care, etc.) • be able to utilize a well-built clinical question to facilitate an efficient search • understand the 4S approach to organizing medical evidence
What is EBM? Evidence Based Medicine (EBM) is defined as the practice of medicine that ‘requires the integration of the best research evidence with our clinical expertise and our patient’s unique values and circumstances’. • Source: Straus SE, Richardson, WS, Glasziou P, Haynes RB. Evidence-Based Medicine: How to Practice and Teach EBM, 3rd ed. New York: Elsevier Churchill Livingstone, 2005.
Definitions • Best research evidence: • ‘Valid and clinically relevant research’. • Clinical expertise: • ‘Ability to use our clinical skills and past experience to rapidly identify each patient’s unique health state and diagnosis, their individual risks and benefits of potential interventions, and their personal circumstances and expectations ‘.
Focused Approach Saves Time • You will not have time to read all of the important articles in the literature • 500,000 new medical articles published each year • You will be expected to quickly make increasingly complex decisions • Sorting the valid information from the less useful takes time away from decision making • You will be expected to “standardize” your practice • Standard of care critical in health care reform and legal issues
New Skills • Efficient literature searching • Evaluate the literature according to formal rules of evidence
Information Retrieval for Evidence Based Patient Care • Using research findings versus conducting research • Retrieving and evaluating information that has direct application to specific patient care problems • Selecting resources that are current, valid, and available at point of care • Developing search strategies that are feasible within time constraints of clinical practice
Steps to Practice EBM • Convert information need into answerable clinical question • Track down the best evidence to answer the question • Critically appraise the evidence for its validity (closeness to truth) , impact (size of the effect), and applicability (usefulness in practice) • Integrate appraisal with clinical expertise and with patient’s unique values and circumstances
Improvements in EBM Practice • Development of efficient search strategies to retrieve the evidence, e.g., clinical queries in Ovid MEDLINE • Creation of systematic reviews • Development of new clinical decision support tools • Future: Systems that integrate and summarize relevant research evidence about specific clinical problems and link through the EMR to a specific patient’s circumstances
“Using” EBM versus Doing EBM • Rapidly develop and practice EBM with limited time and resources • Use the 4S approach to locate critically appraised content
Information Pyramid Up-to-date, Dynamed, FIRSTConsult, ACP PIER ACP Journal Club Evidence Based Ophthalmology Cochrane and other Systematic Reviews (OVID EBMR) MEDLINE Searches with Clinical Queries SOURCE: Haynes, R. B. (2001). Of studies, syntheses, synopses, and systems: the “4S” evolution of services for finding current best evidence. Evidence-Based Medicine, 6 (2), 36-38. Retrieved 2-07-07 from http://ebm.bmj.com/cgi/reprint/6/2/36
Steps to Using EBM • Convert information need into answerable clinical question • Track down the best evidence to answer the question • Use the 4S approach to locate critically appraised content
Is the Evidence Available? • For many common, clinical issues in Optometry and Ophthalmology, there are few acceptable sources to guide decision making • Implementation of evidence-based practice in optometry, p. 240
Using EBM – Step 1 • Frame the well built clinical question • Arises from the clinical encounter • Used to initiate search for evidence • Four basic types of clinical questions • Therapy/prevention • Diagnosis • Etiology • Prognosis
Selecting the Question • Begin with the patient encounter • Which question • is most important to the patient’s well being • fills gaps in your clinical knowledge • is feasible to answer in the time available
Foreground Clinical Questions • Deal with patient management issues • Contain elements of PICO format • Patient/Population • Intervention • Comparison Intervention (if useful) • Outcome • Facilitate an efficient search
Example – Therapy Question • In patients with open angle glaucoma (POAG), does IOP lowering treatment (medical or surgical) versus no treatment delay visual field loss?
Search Terms • Therapy Question • In patients with open angle glaucoma (POAG) [Patient/Population], does IOP (intraocular pressure) lowering treatment (medical or surgical) [Intervention] versus no treatment [Comparison Intervention], delay visual field loss [Outcome]? • Search Terms: open angle glaucoma, POAG, IOP, intraocular pressure, visual field loss
Type of question leads to type of study to best answer the question
Randomized controlled trials are considered the best studies for assessing therapeutic interventions. Source: Sackett, D.L., Richardson, W.S., Rosenberg, W.M.C., & Haynes, R.B. (1996). Evidence-Based Medicine: How to practice and teach EBM. London: Churchill-Livingstone.
Evidence Pyramid • Number of studies fewer at higher levels of the pyramid, but of higher quality and relevance to clinical practice
Using EBM – Steps 2 & 3 • Track down the evidence to answer the question • Use the 4S approach to select the most likely resource • Start with the highest level resource available
Systems • Dynamed • Summaries for more than 3000 topics • Monitors >500 medical journals and systematic review databases • Updated daily • Each article evaluated for clinical relevance and scientific validity
Databases 1:39
Synopses • A step down from Systems • Useful when no answer can be found in the Systems • Summary of individual studies and reviews • Faster than reviewing the individual studies • Examples: ACP Journal Club, Evidence Based Ophthalmology
Synopses • ACP Journal Club • 1991-2009 archive of cumulative content • Periodically thinned • Selected from >100 journals • Published monthly • “Structured abstracts”, critically appraised • Commentaries on context, methods, and clinical applications by expert clinicians • IM focus (Tx, Px, Harm, and Dx)
Synopses • Evidence Based Ophthalmology • Quarterly journal includes reviews of 24 critically relevant articles from ocular literature • Editorial board comprised of practicing physicians with expertise in epidemiology and clinical trials • Search NSU Journals@Ovid
Syntheses • Systematic reviews • Supplement Synopses with more detail • Compare findings • Cochrane Database of Systematic Reviews is the premiere example
Syntheses • Cochrane Database of Systematic Reviews • Part of the Cochrane Library (1996) • 916 completed reviews, 1905 protocols • Among the highest level of evidence upon which to base treatment decisions • Includes Dx since 2008 • Eyes & Vision Research Group • Contains 136 reviews
Systematic Review • Analyzes data from several primary studies to answer a specific clinical question • Provides search strategies and resources used to locate studies • Includes specific inclusion and exclusion criteria (results in less bias) • Meta-Analysis (subclass) statistically summarizes results of several individual studies • Access through OVID
Syntheses • All Evidence Based Medicine Reviews • Database of seven EBM Resources • ACP Journal Club (synopsis) • Database of Abstracts of Reviews of Effects (DARE) (synthesis) • Cochrane Database of Systematic Reviews (synthesis) • Access through Ovid • Expands search for summaries/reviews
Original Studies • Synopses and syntheses take 6 months to years to appear • If the other “S’s” don’t provide the answer, search for studies • Must critically appraise the evidence yourself. Understand and apply measures of internal/external validity • Least efficient (in terms of time) for clinical questions
Primary (Original) Studies • Articles that report results of original research investigations • Conclusions supported by data and reproducible methodology • Good Source: MEDLINE (OVID)
Databases • MEDLINE • Premiere biomedical database from the NLM (National Library of Medicine) • Covers 1950-present • Indexes >4000 international biomedical journals • Full text available for many articles • Access through Ovid