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Francesco NICOTRA

Francesco NICOTRA. Macchine Molecolari per il Trasporto e il Rilascio Selettivo di Farmaci.  DIPARTIMENTO DI BIOTECNOLOGIE E BIOSCIENZE. Fluorescent. Molecular Machinary for Drug Transport and Release. Iminosugars, RAS inhibitors Tyrosine kinase inhibitors. Folic acid RGD, …. Estrogens.

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Francesco NICOTRA

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  1. Francesco NICOTRA Macchine Molecolari per il Trasporto e il Rilascio Selettivo di Farmaci  DIPARTIMENTO DI BIOTECNOLOGIE E BIOSCIENZE

  2. Fluorescent Molecular Machinary for Drug Transport and Release Iminosugars, RAS inhibitors Tyrosine kinase inhibitors Folic acid RGD, …. Estrogens Drug ligand Linker internalisation -S-S- or acid labile or glucuronic acid or photolabile Endocytosis Permeabilization after cleavage Selective tansport mechanisms

  3. Protein (cell)-ligand bindingstudies by NMR L:P 20:1 1 mM : 50 μM 5+RAS-GDP STD-1D on-resonance freq. = 401.44 Hz 5+RAS-GDP 1H Peri F., Airoldi C., Colombo S, Mari S, Jiménez-Barbero J., Martegani E., Nicotra F. Chem. Eur. J., 2006, 3707

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