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Why do some survive Ebola?

Why do some survive Ebola?. By A. CRIQUI R. NEMOZ. PRESENTATION - I. Etiology Filoviridae virus (RNA-) Four subtypes. Ebola infected patient. PRESENTATION - II. Etiology Symptoms Fever Diarrhoea Vomiting Haemorrhage. www.virus-ebola.com October 22, 2002. PRESENTATION - III.

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Why do some survive Ebola?

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  1. Why do some survive Ebola? By A. CRIQUI R. NEMOZ Ebola virus - CRIQUI NEMOZ - December 4 2003

  2. PRESENTATION - I • Etiology • Filoviridae virus (RNA-) • Four subtypes Ebola virus - CRIQUI NEMOZ - December 4 2003

  3. Ebola infected patient PRESENTATION - II • Etiology • Symptoms • Fever • Diarrhoea • Vomiting • Haemorrhage www.virus-ebola.com October 22, 2002 Ebola virus - CRIQUI NEMOZ - December 4 2003

  4. PRESENTATION - III • Etiology • Symptoms • Epidemiology • Endemic zone • Death rate • Transmission • Expression of the disease www.adam.com October 22, 2002 Ebola is still limited to parts of Africa Ebola virus - CRIQUI NEMOZ - December 4 2003

  5. PRESENTATION - IV • Etiology • Symptoms • Epidemiology • Treatment • Not found yet Ebola virus - CRIQUI NEMOZ - December 4 2003

  6. VIRUS TARGETS NE LC sGP Virus EC GP Replication Macro Mono Ebola virus - CRIQUI NEMOZ - December 4 2003

  7. HUMORAL RESPONSE IN FATALITIES IN SURVIVORS • No IgG • Few IgM EM Leroy - The lancet – Vol 355 – June 24, 2000 DEFECTIVE HUMORAL RESPONSE Ebola virus - CRIQUI NEMOZ - December 4 2003

  8. ANTIGEN LOAD  No effect of antigen load on IgG production Baize – Nature medicine Vol 5 #4 – April 1999 Circulating antigen load Ebola virus - CRIQUI NEMOZ - December 4 2003

  9. Acute phase : No T cells activated Clinical recovery : Cytotoxic cells activated Too early Too excessive CELLULAR RESPONSE IN SURVIVORS IN FATALITIES T cells death Ebola virus - CRIQUI NEMOZ - December 4 2003

  10. APOPTOSIS Apoptosis signal Bcl-2 BAIZE – Apoptosis vol 5 #1 - 2000 41/7 NMP (U/ml) PBMC 41/7 NMP is the evidence of apoptosis Ebola virus - CRIQUI NEMOZ - December 4 2003

  11. CONCLUSION • Different immune responses • Prevention of transmission • Perspectives Different expressions of the disease Ebola virus - CRIQUI NEMOZ - December 4 2003

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