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BIOMONITORING:

BIOMONITORING:. A PLAN FOR DELAWARE DELAWARE CANCER CONSORTIUM RETREAT FEBRUARY 15, 2010. Karen Nunley, M.S. MULTI-MEDIA EXPOSURE STUDY. Introduction Biomonitoring Benefits Limitations Delaware’s Plan Discussion / Q & A. MULTI-MEDIA EXPOSURE. MULTI-MEDIA EXPOSURE.

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BIOMONITORING:

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  1. BIOMONITORING: A PLAN FOR DELAWARE DELAWARE CANCER CONSORTIUM RETREAT FEBRUARY 15, 2010 Karen Nunley, M.S.

  2. MULTI-MEDIA EXPOSURE STUDY • Introduction • Biomonitoring • Benefits • Limitations • Delaware’s Plan • Discussion / Q & A

  3. MULTI-MEDIA EXPOSURE

  4. MULTI-MEDIA EXPOSURE

  5. CHEMICALS ENTER THE BODY VIA: • Dermal Absorption • Inhalation • Ingestion • Injection

  6. MULTI-MEDIA EXPOSURE

  7. WHAT IS BIOMONITORING? • Measuring human tissue and bodily fluids for the presence of chemicals or their metabolites

  8. WHAT IS BIOMONITORING? • Measuring human tissue and bodily fluids for the presence of chemicals or their metabolites • Provides information about the ‘internal’ dose rather than the ‘external’ concentration

  9. EFFECTS DEPEND ON: • Exposure route • Exposure duration • Exposure frequency • Exposure intensity

  10. HISTORY • Used in late 1800s to test workers for lead and to monitor salicyluric acid levels in people being treated for rheumatism • Historically used in occupational settings

  11. HISTORY • In the last few decades, expanded to measure chemical exposures in the general population

  12. BIOMARKERS • Exposure • Effect • Susceptibility

  13. All substances are poisons; there is none which is not a poison. The right dose differentiates a poison from a remedy (Paracelsus, 1567)

  14. BENEFITS

  15. LIMITATIONS

  16. Only a snapshot of exposure • Exposure  Disease • Cannot reveal exposure sources or routes • Influence of personal behaviors, genetics • Unknown additive/synergistic effects of chemicals • Ethical issues

  17. DELAWARE’S BIOMONITORING PLAN

  18. DELAWARE’S BIOMONITORING PLAN • Pilot three target areas • Approximately 400 Delawareans ages18 and older • Samples collected summer and winter; repeat over 2-3 years • Expand to statewide sampling

  19. DELAWARE’S BIOMONITORING PLAN • Testing for variety of substances • Blood, urine, hair samples • Extensive questionnaire • Environmental Samples • Water, air, soil/dust

  20. DELAWARE’S BIOMONITORING PLAN • Prospective Study • Archive samples for future testing • Create database

  21. DATABASE FUNCTIONS: • Detect which chemicals are present in Delawareans, and in what concentrations • Regional exposure variance • Exposure disparities • Monitor changes over time • Evaluate Public Health programs

  22. FUTURE USES: • Enact and evaluate effectiveness of exposure reduction strategies • Support legislation • Provide data to support future epidemiological studies via linkage to disease and hospitalization records • Decrease uncertainty inherent in exposure risk assessments

  23. WILL NOT: • Sample every Delawarean • Provide full exposure history • Identify exact exposure source(s) or disease causation • Identify who will or will not develop a disease endpoint

  24. Q & A

  25. THANK YOU! Karen Nunley, M.S.

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