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Language disorders in Progressive Supranuclear Palsy: an underestimated condition?

This study explores cognitive dysfunction and language abilities in Progressive Supranuclear Palsy (PSP) patients, highlighting the importance of speech and language deficits in PSP subgroups. The presence of language disorders, particularly in PSP-Richardson’s Syndrome, indicates a need for greater attention to this aspect of the condition.

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Language disorders in Progressive Supranuclear Palsy: an underestimated condition?

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  1. Language disorders in Progressive Supranuclear Palsy: an underestimated condition? E. Del Prete, L. Tommasini, D. Frosini, S. Mazzucchi, A. Bruno, U. Bonuccelli, R. Ceravolo DIPARTIMENTO DI MEDICINA CLINICA E SPERIMENTALE, U.O. NEUROLOGIA, UNIVERSITÀ DI PISA, PISA

  2. Background: PSP is characterized by specific neuropsychiatric and cognitive dysfunction. The pattern of early cognitive impairment in PSP is usually a dysexecutive frontal syndrome but language domains could also be affected. New criteria for clinical diagnosis of PSP have recently been published by the Movement Disorders Society. • Cognitive dysfunction is now considered one of four core features and speech/language deficit is gaining more relevance. Hoglinger, Movement Disorders, 2017

  3. Objectives: we aimed to investigate executive functions and languages abilities in PSP patients and in Progressive Supranuclear Palsy subgroups [PSP-Richardson’s Syndrome (PSP-RS) and PSP-non-RS] according to new Movement Disorders Society criteria. PSP-RS PSP-RS PSP with Richardson’s syndrome PSP-OM PSP with predominant ocular motor dysfunction PSP-PI PSP withpredominantposturalinstability PSP-P PSP withpredominantparkinsonism PSP-F PSP withpredominantfrontalpresentation PSP-CBS PSP withpredominant CBS PSP-PGF PSP with progressive gaitfreezing PSP-SL PSP with predominant speech/ language disorder PSP-non-RS

  4. Methods 15 PSP-RS 22 PSP patients 7 PSP-non-RS(3 PSP-CBS, 3 PSP-P, 1 PSP-SL) Clinical Evaluation PSP-Rating Scale Apathy Evaluation Scale; Beck Depression Inventory II Global cognitive status (MMSE), Attention & Working Memory (DigitSpanFoward & Backward), Executive Functions (FAB) LanguagesAbilities FAS, SemanticFluency Test, AAT naming test and SAND (Screening for Aphasia in NeuroDegeneration)

  5. Results

  6. Results * * * The presence of language disorders could be part of PSP-RS phenotype. In our cohort PSP-RS show simplified syntactic structures with paucity of used verbs even if the impairment does not meet criteria for definite agrammatism.

  7. Grazie per l’attenzione

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