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Major Histocompatibility Antigens and Transplantation Immunobiology Lecture 17 November 9, 2010

Major Histocompatibility Antigens and Transplantation Immunobiology Lecture 17 November 9, 2010.

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Major Histocompatibility Antigens and Transplantation Immunobiology Lecture 17 November 9, 2010

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  1. Major Histocompatibility Antigens and Transplantation Immunobiology Lecture 17 November 9, 2010

  2. LAHORE, 27 October 2008 (IRIN) - Pervaiz Masih, 32, is taking particular care of his diet these days. "I try to eat some meat and drink at least one glass of fruit juice a day. I need to be healthy because then it is more likely someone will buy my kidney," he told IRIN. Masih, a labourer, earns about Rs 4,000 (about US$50) a month. With three children to support, he says it is impossible to survive on his income. The family has accumulated heavy debts, owed to neighbours, relatives and shopkeepers. "The only way I can pay off these debts of around Rs 100,000 [US$1,250] is if I sell a kidney. I have been in touch with some agents from a hospital in Lahore and have been told I could get Rs 200,000 [about $2,500] or even more if a wealthy Pakistani or foreigner buys my kidney." Before September 2007, Pakistan was known as a major world centre for “renal tourism”. The lack of laws governing the donation and transplant of kidneys made it easy for people needing a new organ to visit Pakistan and buy one - usually from destitute people desperate for cash. PAKISTAN: Under pressure to sell a kidney

  3. Prison for US body part snatchers Thursday, 23 October 2008 Three men who admitted conspiring to sell on body parts harvested from corpses in the United States have been given at least eight years in prison. A Philadelphia court jailed Louis and Gerald Garzone, who ran funeral homes in the city, from eight to 20 years. The scheme's mastermind, Michael Mastromarino, was handed 25 to 58 years - to run concurrently with a similar sentence already received in New York. The body parts were sold to biomedical firms without the consent of relatives. Mastromarino described his crimes as "disgusting and embarrassing"

  4. The T-cell receptor It is a heterodimer consisting of an alpha and beta chain in 95% of T cells, while 5% of T cells have TCRs consisting of gamma and delta chains.

  5. V D J V J No somatic mutation During T cell development, palindrome, recombination, excision occurs.

  6. T cytotoxic T helper All nucleated Ag presenting

  7. Karl Landsteiner, 1930 During WW1,1914-1918, blood transfusions were attempted and patterns of rejection noted. The 1930’s in the US was the Great Depression. . Blood Group antigens

  8. Cell surface Blood Group antigens • MAJOR- ABO T cell independent antigens • MINOR- Duffy, Rh factor (D antigen) other T cell dependent antigen

  9. 1943 on - many reports of treatment of burns with skin

  10. Notice scale expanded

  11. Peter Gorer and George Snell • Mouse strain A bred with Mouse Strain B • F1 generation • F1 accepts skin graft from either parent • Neither parent accepts skin graft from F1 • Thus it is a inherited trait.

  12. In humans Recipient cells Donor cells + Mitomycin C If no increase in cell Doubling of Extensive Proliferation Number Cell Number OK to transplant Possibility of Rejection Acute Rejection

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