Molecular Genetics Jeopardy

1. Molecular Genetics Jeopardy Vocab DNA structure/ Replication Transcription Translation Mutations $100 $100 $100 $100 $100 $200 $200 $200 $200 $200 $300 $300 $300 $300 $300 $400 $400 $400 $400 $400 $500 $500 $500 $500 $500 Final Jeopardy

2. What happens in transcription and translation? Transcription: mRNA molecule made from DNA Translation: amino acid sequence made from mRNA 1 - $100

3. 1 - $200 • What enzyme adds nucleotides to a growing piece of DNA during DNA replication? • DNA polymerase

4. 1 - $300 • What are the three types of RNA • mRNA, tRNA, rRNA

5. 1 - $400 • What are introns and exons? • During mRNA processing, introns are cut out and exons stay in

6. 1 - $500 • What is this called (circled) and what are each of the parts called • Nucleotide-made up of sugar, phosphate and nitrogenous base

7. 2 - $100 • What are the bases that make up DNA? Which pair with which? • Adenine-thymine, cytosine-guanine

8. 2 - $200 • What protein unwinds DNA during replication? • helicase

9. 2 - $300 • If one strand of DNA reads: 3’ ATGCGTA 5’ what will the other strand read? • 5’ TACGCAT 3’

10. 2 - $400 • Why is DNA replication called semi-conservative?

11. 2 - $500 • Label the parts of DNA replication. A • A-helicase • B-leading strand • C-lagging strand • D-DNA polymerase • E-5’ • F-3’ B C D

12. 3 - $100 • What is the product of transcription? • mRNA molecule

13. 3 - $200 • If the DNA sequence of a gene begins with ATGCTG, what will the mRNA read after transcription? • UACGAC

14. 3 - $300 • Where does transcription occur and why? • In the nucleus because DNA is in the nucleus

15. 3 - $400 • What are three differences between DNA and RNA? • DNA is double stranded, has deoxyribose sugar, has T instead of U

16. 3 - $500 • What happens during mRNA processing? ? • Introns spliced out, 5’ cap and poly A tail

17. 4 - $100 • Where does translation occur? • ribosome

18. 4 - $200 • What is this molecule called? • tRNA

19. 4 - $300 • What are codons and anticodons? • Codons=3 base pairs of mRNA that code for an amino acid • anticodon-=complementary sequence on tRNA molecule

20. 4 - $400 • If an mRNA sequence reads AUGGAU, what will the anti codons of the tRNA molecules that bind to the mRNA be? • UAC, CUA

21. 4 - $500 • If an mRNA sequence reads AUG CCA GUG, what will the sequence of amino acids be after translation? • Met, pro, val

22. 5 - $100 • What type of mutation is this? • Normal: ACGAGG • Mutated: CGAGG • Deletion, frameshift

23. 5 - $200 • What type of mutation is this? • Normal: AGTGTA • Mutated: AGTGATA • Insertion, frameshift

24. 5 - $300 • Why is the difference between a frameshift and a substitution mutation? • A frameshift changes all amino acids after the mutation

25. 5 - $400 • What is it called if a mutation leads to a codon changing to a stop codon? • nonsense

26. 5 - $500 • What is the difference between missense, nonsense and silent mutations? • Missense-changes one amino acid • Nonsense-changes to a stop codon • Silent-doesn’t change amino acid

27. Final Jeopardy • Given the following template strand DNA sequence, what will the mRNA produced from transcription be? What will the amino acid sequence after translation be? • TACGGAACGCTG