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YOUNG'S MODULUS

YOUNG'S MODULUS EVALUATION FOR BLOOD VESSEL EQUIVALENT PHANTOMS USING OPTICAL COHERENCE ELASTOGRAPHY. Potlov A.Yu, Frolov S.V., Proskurin S.G. Biomedical Engineering, TSTU http://bmt.tstu.ru/ zerner@yandex.ru. Saratov Fall Meeting 201 8. RELEVANCE.

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YOUNG'S MODULUS

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  1. YOUNG'S MODULUS EVALUATION FOR BLOOD VESSEL EQUIVALENT PHANTOMS USING OPTICAL COHERENCE ELASTOGRAPHY Potlov A.Yu, Frolov S.V., Proskurin S.G. Biomedical Engineering, TSTU http://bmt.tstu.ru/ zerner@yandex.ru Saratov Fall Meeting 2018

  2. RELEVANCE Cerebral aneurysm affects 3-5% of the adult population More than 60% die from aneurysm rupture (stroke) The chances of aneurysm rupture depends on many factors: the patient's lifestyle, the stress-related properties of the patient’s blood vessel walls, the geometric features of the aneurysm, the specific features of the patient’s cardiovascular system, and so on. 2

  3. FLOW-DIVERTER The medical product used in the complex shape cerebral aneurysms treatment. Complex shapemeans spindle-shaped aneurysms, wide-neck aneurysms, etc. The correct selection of the flow-diverter is hampered without using the stress-related propertiesof the patient’s blood vessel wall 3

  4. PROTOTYPE OF THE EXPERIMENTAL SETUP Fiber optic reusable endoscopic probe Optical fiber interferometer with an electro-optical piezo-fiber depth scanning "OCT 1300-E" («Biomedtech», Nizhny Novgorod, Russia) 4

  5. SIMPLIFIED SCHEME OF THE EXPERIMENTAL OCT SYSTEM 1 - light source; 2 - single-mode optical fiber; 3 - optical splitter; 4 - sample arm fiber; 5 - endoscope probe connector; 6 - flexible endoscopic probe; 7 - catheter of the endoscopic probe; 12 - a transparent catheter's shell; 13 - fiber bundle; 19 - focusing lens; 20 - computation and imaging unit; 21 - reference arm single-mode fiber; 22 - focusing lens; 23 - neutral density filter; 24 - optical splitter; 25 - spectrometer. Patent pending, Positive decision 2018 5

  6. SIMPLIFIED SCHEME OF THE ENDOSCOPIC PROBE 8 - optical splitter, 9 - first single-mode optical fiber, 10 - collimator, 11 - focusing lens, 14 - second single-mode optical fiber, 15 - optical trigger, 16 – MEMS gyroscope, 17 – MEMS accelerometer, 18 - digital signal processor, 19 - focusing lens of the sample arm Patent pending, Positive decision 2018 6

  7. ALGORITHM FOR ESTIMATING YOUNG'S MODULUS Biomedical Engineering, 2018, Vol. 51, p. 381-384 7

  8. ALGORITHM FOR FORMATION OF THE BLOOD VESSEL PHANTOM Patent pending, Positive decision 2018 8

  9. OCT IMAGES OF THE BLOOD VESSELWALL PHANTOM Structural OCT images of phantom of optical and stress-related properties of the soft biological tissue before (a) and after (b) deforming impact (a) 9 (b)

  10. PROCESSING OF RECEIVED BIOMEDICAL DATA Displacements of the internal structures of the investigated object Within normal limits Biomedical Engineering, 2018, Vol. 51, p. 381-384 10

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