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Teachable Tidbit: Cell Signaling—Why should YOU Care?

This Teachable Tidbit explores the importance of cell signaling in regulating cell division and how defects in these pathways can lead to cancer. Participants will learn about the various components involved in cell signaling and discuss potential treatments for cancer.

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Teachable Tidbit: Cell Signaling—Why should YOU Care?

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  1. Teachable Tidbit: Cell Signaling—Why should YOU Care? Mountain West Summer Institute August 3, 2012 Group 1: Cell Biology Participants: Patrick Burns, Jacquelyn Duke, Diane Hartman, Pamela Harvey, Andrea Stith, and Mark Thomas Facilitators: Renee Dawson and Robin Wright

  2. Overview • Topic: Cell signaling and cancer • Context: • Week-long unit geared toward 100-level biology course for majors and non-majors. • End of semester • 50 to 100 students • Prior Knowledge: • Cell structure • Mitosis • Reading assignment on cell signaling

  3. Unit Goals • Understand that cell signaling regulates cell division • Understand that defects in cell signaling underlie cancer

  4. Tidbit: Outcomes & Activities

  5. What do these people have in common?

  6. What IS cancer? • Will there ever be a cure?

  7. Cell Division and Cancer

  8. Cell Division Go STOP

  9. Cell Division A B C ___Transduction Pathway ___Nuclear Envelope ___Plasma Membrane ___Growth Factor Receptor ___Growth Factor ___Tumor Suppressor Gene Go D E F STOP

  10. Regulators of Cell Division

  11. Summary Assessment Question Jane recently was diagnosed with breast cancer. The oncologist performed a biopsy and laboratory analysis revealed an increase in HER2 receptors and decreased p53. You work in a pharmaceutical company and are a genius at drug design. Brainstorm a way to treat Jane’s cancer.

  12. Take home messages: Appropriate cell signaling is required for normal cell division. Cancers are caused by defects in cell signaling pathways. Multiple defects magnify the severity.

  13. Assessment, Alignment, & Diversity

  14. Thank you! Facilitators, Group Members & National Academies Summer Institute for your contributions!

  15. Website Citations • 1 http://trussty-jasmine.blogspot.com/2012/03/stem-cells-can-repair-damaged-corneas.html#axzz22P5vt5SP • 2 http://www.buyactivatedcharcoal.com/infected_wounds • 3 http://en.wikipedia.org/wiki/Human_skeleton

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