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Workshop Physicians Treatment failure and HIV resistance

Objectives of workshop. Understanding the basic mechanisms of HIV resistanceHow to assess treatment failure?Understanding strategies in managing patients with (suspected) treatment failure . Q

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Workshop Physicians Treatment failure and HIV resistance

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    1. Workshop Physicians Treatment failure and HIV resistance Facilitors Dr Ponsiano Kaleebu MRC, Uganda Prof JoepLange PharmAccess/CPCD/AMC, The Netherlands

    2. Objectives of workshop Understanding the basic mechanisms of HIV resistance How to assess treatment failure? Understanding strategies in managing patients with (suspected) treatment failure

    3. Q & A’s on the basics of HIV resistance

    4. HIV can develop resistance quickly under monotherapy Can you explain why?

    5. Why HIV resistance can develop easily ….. HIV reproduces rapidly Billions of new viruses every day While copying itself, the virus continuously makes mistakes ? a new generation of viruses develops which differs slightly from the one before

    6. Thus ……… A very large virus population with an extremely high genetic diversity develops Every thinkable mutation may develop In a patient a cloud of “Quasi-species” exists

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