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Watch the ALZET Osmotic Surgery Implant Video Now let’s discuss Transdermal Delivery of Drugs

Watch the ALZET Osmotic Surgery Implant Video Now let’s discuss Transdermal Delivery of Drugs 1. Drug molecules diffuse across the skin 2. enter the systemic circulation 3. skin can be a BIG permeability barrier 4. best for drugs with high pharmacological activity (potent)

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Watch the ALZET Osmotic Surgery Implant Video Now let’s discuss Transdermal Delivery of Drugs

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  1. Watch the ALZET Osmotic Surgery Implant Video Now let’s discuss Transdermal Delivery of Drugs 1. Drug molecules diffuse across the skin 2. enter the systemic circulation 3. skin can be a BIG permeability barrier 4. best for drugs with high pharmacological activity (potent) and good skin permeability (lipophilic) Nictoine patch

  2. Stratus corneum major resistance for drug transport -15 layers of keratinocytes -space between cells filled with lipid bilayers

  3. 3 issues with diffusion of the drug 1. diffusion in the device or patch 2. diffusion across the SC 3. disposition of drug in underlying tissue 4. distribution of drug throughout the body (PK)

  4. Approx. This result is from the previous 2 slides rigorous

  5. Assuming the controlling resistance for diffusion of the drug is the SC, then the drug concentration within the patch is basically flat and we can write

  6. Predicting the permeability of the skin or the SC Useful for preliminary feasibility calculations in the absence of hard data

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