1 / 7

5 Types of COVID-19 Vaccines

Existing COVID-19 vaccines mainly include inactivated vaccines, recombinant subunit vaccines, viral vector vaccines, nucleic acid vaccines and virus-like particles (VLPs) vaccines. This article mainly summarizes these five types of COVID-19 vaccines and their characteristics.

sunnyfang1419
Download Presentation

5 Types of COVID-19 Vaccines

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Huateng Pharma https://us.huatengsci.com 5 Types of COVID-19 Vaccines Since the outbreak of COVID-2019 in December 2019, as of April 2022, according to the World Health Organization (WHO) statistics, there have been more than 500 million confirmed cases worldwide, of which more than 6.1 million died. In the context of the COVID-19 global pandemic, vaccination has become the key to controlling the spread of the COVID-19 in the population. Existing COVID-19 vaccines mainly include inactivated vaccines, recombinant subunit vaccines, viral vector vaccines, nucleic acid vaccines and virus-like particles (VLPs) vaccines. This article mainly summarizes these five types of COVID-19 vaccines and their characteristics. New confirmed cases, by date of report 1. Inactivated Vaccines Inactivated vaccines kill the virus to lose its infectivity and virulence, but still have immunogenicity and are combined with corresponding adjuvants. It is characterized by good safety, the most complete immunogenicity, rapid early development and mild adverse reactions. However, inactivated vaccines mainly cause humoral immunity, and cellular immunity is rarely detected, so the protection rate of vaccines is relatively low. are vaccines that use physical or chemical methods to Currently, there are mainly two inactivated vaccines China: Sinopharm (Beijing) BBIBP-CorV (Vero Cells) and Sinovac against COVID-19 in

  2. Huateng Pharma CoronaVac. marketing in China, and the data show that its protection rate is 79.34%[1]. Inactivated vaccine is also the most widely used vaccine for clinical prevention. Inactivated vaccines include SARS-COV-2 Vaccine from the Institute of Medical Biology, Chinese Academy of Medical Sciences (IMBCAMS), and Inactivated (Vero Cell) Vaccine is under development. https://us.huatengsci.com The former is the first COVID-19 vaccine approved for Schematic diagram of inactivated vaccine preparation principle Image source: WHO 2. Recombinant Subunit Vaccines Recombinant subunit vaccines antigen genes in prokaryotic or eukaryotic cells products, i.e. proteins or peptides, and corresponding adjuvants. It is characterized by high purity, good stability and high safety. A three-dose vaccination programme is generally used. Zhifei COVID-19 vaccine is the world's first recombinant COVID-19 vaccine approved for use. The vaccine is made by expressing purified SARS COV-2 S-RBD dimer antigen protein in Chinese Hamsters Ovary (CHO) through genetic engineering, supplemented with Al(OH)3 adjuvant [4]. are vaccines that express protective and are made with gene A moderate Th1/Th2 mixed-type generated after vaccination. The results of phase III clinical trials showed that the overall protective efficacy of the vaccine against all symptoms was 81.43%, and the protective efficacy against severe cases could reach 100%. At present, recombinant subunit vaccines have been vaccinated in some areas, and no serious adverse reactions have been found. The recombinant subunit vaccines under development include SK Bioscience's GBP510 vaccine, WestVac Biopharma's Recombinant COVID-19 Vaccine, and Cinnagen's SpikoGen vaccine. cellular immune response can be 3. Viral Vector Vaccines

  3. Huateng Pharma https://us.huatengsci.com Viral vector vaccines are vaccines material coding for a desired antigen into the recipient's host cells. characterized by the ability to induce continuous and effective humoral and cellular immune responses. However, the adverse reactions are relatively severe compared with inactivated vaccines, and are not suitable for immunocompromised people. The pre-existing immunity of viral vectors may interfere with the effect of vaccines. that use a viral vector to deliver genetic It is The world's first viral vector vaccine entering clinical trials is the human adenovirus vector COVID-19 vaccine (AD5-NCOV) from China, which was jointly developed by the team of Academician Chen Wei of the Academy of Military Medical Sciences and CanSinoBIO. The vaccine was constructed by cloning the full-length S gene containing tissue-type plasminogen activator signaling peptide gene into replication-deficient human adenovirus type 5 [2]. The mid-term results of phase III clinical trials showed that the protective efficacy of a single dose of vaccine against severe diseases was 96.0% and 91.7% after 14 and 28 days, respectively [3]. In addition, the existing adenovirus vector vaccines designed by the United Kingdom, Russia and other countries have shown rapid cellular immunity and humoral immunity after inoculation, and clinical data show that they have a high protective power, especially for severe patients, which can reach more than 90%. Currently, adenovirus vector vaccines under development include Sputnik V vaccine from Russia and AD26.cov2.s developed by Janssen– Cilag International NV. Schematic diagram of Ad5-nCoV structure

  4. Huateng Pharma https://us.huatengsci.com Image source: Savina et al. Beni-Suef Univ J Basic Appl Sci (2022) 11:35 4. Nucleic Acid Vaccines Nucleic acid vaccine is a kind of vaccine that introduces the gene encoding antigen protein (DNA or RNA) into the host cell, uses the expression system of the host cell to synthesize antigen protein and induce the host to produce immune response to the antigen, so as to prevent diseases [5]. vaccines are divided into DNA vaccines and mRNA vaccines. vaccine is characterized by short development cycle and flexible design, which can superimpose multiple antigen mRNA to enhance immunity. Moreover, exogenous mRNA itself has antigenicity and does not need adjuvants to enhance immune response. However, mRNA vaccines are unstable and require effective delivery systems (e.g. nanoparticles coated with liposomes) to enter cells and play an antigenic role. Nucleic acid mRNA Moderna's COVID-19 vaccine (mRNA-1273) is the first vaccine to enter clinical trials in the world. Phase I and II clinical results showed that this vaccine can rapidly induce neutralizing antibodies and produce TH1-biased T cell immune response. In phase III clinical trials, no safety problems were found except transient local and systemic reactions, and the vaccine effective rate was 94.1%[6]. In addition, the mRNA vaccine developed by Pfizer also produced strong immune effects in the clinical stage. Current mRNA vaccines under development include CSPC mRNA vaccine (SYS6006), CanSinoBIO mRNA vaccine and Moderna's (mRNA-1273.214). new generation mRNA vaccine LNP-encapsulated mRNA vaccine structure Image source: Savina et al. Beni-Suef Univ J Basic Appl Sci (2022) 11:35

  5. Huateng Pharma In addition to mRNA vaccines, DNA vaccines have also been applied to the COVID-19 vaccines. DNA vaccine is to implant the DNA fragment of the target antigen into the plasmid, which is brought into the host cell by the plasmid. The DNA molecule is very stable, it can exist in the host cell for a long time, and continuously generate natural antigens in the body to trigger a sustained and effective immune effect. However, it may also integrate into the chromosome of the host cell causing mutations. https://us.huatengsci.com The first DNA vaccine to enter the clinic is INO-4800 produced by Inovio Pharmaceuticals in the United States. Clinical results show that the vaccine can induce a strong S protein specific T cell response and produce neutralizing antibodies. The current research is mainly on the new generation of DNA vaccines from Advaccine. Schematic diagram of DNA vaccine structure 5. Virus-like Particles (VLPs) Vaccines Virus-like particles (VLPs) vaccines multimeric particles similar to the spatial structure of natural virus particles, which contain hollow particles of one or more structural proteins of a certain virus, without viral nucleic acids that are identical or similar in morphology to true virions. It is characterized by having a three-dimensional structure and composition similar to natural virus particles, which can stimulate the human immune system through a route similar to virus infection, and efficiently induce the human body to produce an immune protection response. refer to a class of vaccines with

  6. Huateng Pharma Moreover, VLPs vaccine also has an adjuvant effect. It is becoming a hot spot in vaccine research and development. VLPs vaccines under development include Medicago's COVIFENZ® vaccine. https://us.huatengsci.com Structural biodiversity of VLP Image source: EXPERT REVIEW OF VACCINES, 2018. 17(9): p. 833-849. Another common type of vaccine is attenuated vaccine. An attenuated vaccine is a vaccine created by reducing the virulence of a pathogen, but still keeping it viable (or "live"). Attenuation takes an infectious agent and alters it so that it becomes harmless or less virulent. development cycle of attenuated vaccines is long, and it is necessary to consider whether the virulence of the attenuated strains will become stronger. Under the premise of the COVID-19, it is very challenging. attenuated vaccines are rarely used in COVID-19 vaccines However, the research and Therefore, at present. Conclusion As the novel coronavirus continues to mutate, vaccination is more important than ever. Although the data suggest that vaccination does not completely prevent infection, it can reduce the proportion of severe cases. studies have shown that the level of neutralizing antibodies decreases in patients who recover from COVID-19 seven months after infection, but t-lymphocyte immunity persists. Therefore, cellular immunity induced by T In addition,

  7. Huateng Pharma cells should be considered more in the development of the second generation of COVID-19 vaccine. https://us.huatengsci.com Huateng Pharma is a professional supplier dedicated to providing PEG derivatives and pharmaceutical intermediates to customers worldwide. We can provide CDMO services for COVID-19 drugs and COVID-19 vaccines with sufficient capacity. We can provide custom synthesis for commercial scaleup of COVID-19 oral drug Ensitrelvir (S-217622) and Paxlovid intermediates. We can also supply the some PEG products which used as excipients in COVID-19 vaccines. References: [1] Development of an inactivated vaccine candidate for SARS-CoV-2 [2] A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge [3] Final efficacy analysis, interim safety analysis, and immunogenicity of a single dose of recombinant novel coronavirus vaccine adenovirus type 5 vector) in adults 18 years and older: an international, multicentre, randomised, double-blinded, placebo-controlled phase 3 trial (vol 399, pg 237, 2021) [4] A tandem-repeat dimeric RBD protein-based covid-19 vaccine zf2001 protects mice and nonhuman primates [5] Technical issues in construction of nucleic acid vaccines [6] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

More Related