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Alignment of Comparative Effectiveness through MedaMACS

This article explores the concept of comparative effectiveness research and its role in patient-centered care. It addresses the initial national priorities for comparative effectiveness research and discusses the importance of shared decision making. The focus is on MedaMACS, a system that uses INTERMACS profiles for triage and emphasizes the importance of defining disease severity, frailty, and quality-adjusted survival. The article also highlights the significance of using patient-centered, non-survival outcomes to estimate benefit in ambulatory heart failure patients.

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Alignment of Comparative Effectiveness through MedaMACS

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  1. Alignment of Comparative Effectiveness through MedaMACS Monica R. Shah, M.D. Deputy Chief, Heart Failure & Arrhythmias National Heart, Lung, and Blood Institute (NHLBI) May 5, 2014

  2. Comparative Effectiveness Research & Patient-Centered Care • Definitions & National Priorities • How Does MedaMACS Address These Priorities?

  3. Comparative Effectiveness Research Initial National Priorities for Comparative Effectiveness Research, IOM, 2009

  4. Patient-Centered Care & Shared Decision Making Crossing the Quality Chasm, National Research Council, National Academies Press, 2001 Shared Decision Making – The Pinnacle of Patient-Centered Care, Barry MJ, NEJM, 2012

  5. MedaMACS: CER & Patient-Centered Care • Triage Guided by INTERMACS Profiles • Importance of defining severity of disease before comparing therapies • Frailty and Quality Adjusted Survival • Importance of using frailty to inform patient selection and decision making • Estimating Benefit in Ambulatory HF Patients • Understanding patient-centered, non-survival outcomes

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