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ABC of Boswellia. Our presentation will begin promptly at 10 AM Central The line will be silent until we are ready to begin We will make periodic announcements so that you can test your audio settings. Call 866-569-3239 if you have having any problems hearing the announcements.
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ABC of Boswellia Our presentation will begin promptly at 10 AM Central The line will be silent until we are ready to begin We will make periodic announcements so that you can test your audio settings. Call 866-569-3239 if you have having any problems hearing the announcements. Thank you for attending, and we hope you enjoy the presentation! Sponsored by Telephone: 1-877-668-4493 Access Code: 660 960 027
Welcome! Audio Call this number if you prefer to listen via telephone instead of your computer speakers Telephone: 877-668-4493 Access code: 660 960 027 This information will appear at the bottom of the slides Technical support 866-569-3239 Telephone: 1-877-668-4493 Access Code: 660 960 027
How to Ask Questions Telephone: 1-877-668-4493 Access Code: 660 960 027
Cheryl Myers RN BA • Integrative health author, and natural medicine practitioner • Expert on natural health, and a nationally-recognized speaker who has been interviewed by the New York Times, Wall Street Journal, and Prevention Magazine • A well-known advocate of bridging the worlds of mainstream and natural medicine to achieve optimal health outcomes • Chief of Scientific Affairs and Education for EuroPharma, Inc. Telephone: 1-877-668-4493 Access Code: 660 960 027
Asthma, Bowel, Cancer: The Boswellia A, B, Cs Cheryl Myers Telephone: 1-877-668-4493 Access Code: 660 960 027
5-LOX Arachidonic Acid 5-LOX converts arachidonic acid to inflammatory leutoktrienes and 5-HETE 5-LOX Leukotrienes 5-HETE Joints: osteoarthritis, rheumatoid arthritis, gout Lungs: Asthma, allergies, COPD Cancer: growth of cancer cells, especially prostate cancer Intestines: IBS, inflammatory bowel, colitis, …
Boswellia Modulates 5-LOX Arachidonic Acid Boswellia inhibits 5-LOX, reducing activity of inflammatory leukotrienes and 5-HETE - - - - - 5-LOX Leukotrienes 5-HETE Healthy Cells! Pain Free Joints! Easy Breathing! Predictable Digestion!
Selected compounds in boswellia Gum Terpenes Boswellic Acids resin gum volatile oil arabinose α-thujene camphene D-limonene linalool β-Boswellic Acid α-Boswellic Acid 11-Keto-β-Boswellic Acid Acetyl-α-Boswellic Acid Acetyl-β-Boswellic Acid Acetyl-11-Keto-β-Boswellic Acid AKBA – the MVP
AKBA stops 5-LOX No 5-LOX inhibition by 3α,24-diol (alcohol derivative of beta boswellic acid) Exposure to AKBA (in white blood cells, scientific model) brought about complete inhibition of 5-LOX activity 5-LOX Activity (%)
Intestinal Inflammation and Lung Disease Go Together • Airway disease is the most common associated chronic disease in patients with Crohn’s disease • Patients with Crohn’s or ulcerative colitis are up to 70% more likely to have asthma than controls • Also: psoriasis, rheumatoid arthritis, and multiple sclerosis
Uses for boswellia in Ayurvedic texts (4000 years old – maybe more!) Modern research on boswellia arthritis, asthma, cancer, irritable/inflammatory bowel, pain, liver disease, heart disease arthritis, diarrhea, dysentery, ringworm, boils, fevers, skin and blood diseases, cardiovascular diseases, mouth sores, sore throat, bronchitis, asthma, cough, vaginal discharges, hair loss, jaundice, hemorrhoids, syphilitic diseases, irregular menses and stimulation of liver Telephone: 1-877-668-4493 Access Code: 660 960 027
Research results Telephone: 1-877-668-4493 Access Code: 660 960 027
Boswellia relieves asthma symptoms Standard inhalation therapy alone (control) versus standard inhalation therapy plus oral boswellia 43% reduction in need for inhalation therapy, from 14 inhalations a week to 8 per week by the fourth week of use.
Clinical research - asthma • 40 patients who had asthma for at least 3 years • 300 mg of boswellia, 3x daily for 6 weeks or placebo • Results: • 70% of boswellia patients improved, versus 27% in the placebo group • Easy, less labored breathing, less airway obstruction, fewer asthma attacks, increase in lung function (forced expiratory volume)
Boswellia protects the intestinal barrier Hydrogen peroxide TNFα +INFγ Permeability (% versus control)
Boswellia stops diarrhea Experimentally induced diarrhea in an animal model of irritable bowel syndrome 72% reduction in subjects with diarrhea with the highest dosage of boswellia Subjects with diarrhea (%) BSE extract mg kg-1
Clinical Research – colitis and Crohn’s • Ulcerative colitis • Boswellia, 350 mg 3x daily for 6 weeks or the drug sulfasalazine • 82% of the boswellia patients achieve remission versus 75% of the drug group • Chronic colitis (with abdominal pain and diarrhea) • Boswellia, 300 mg 3x daily for 6 weeks or the drug sulfasalizine • 18 of 20 patients in the boswellia group showed improvement in their symptoms versus 6 out of 10 in the drug group • 14 boswellia patients went into remission versus 4 in the drug group • Crohn’s disease • 83 patients treated with boswellia or standard drug (mesalazine) • Both groups improved, but boswellia group experienced fewer side effects
5-LOX inhibition stops prostate cancer cells from growing Prostate Cancer Cells Exposed to a 5-LOX inhibitor The more 5-LOX is inhibited, the greater the increase in cancer cell death. Decreasing number of cancer cells Cell Viability (%) LNCaP cells
Pancreatic cancer Pancreatic cancer tumors (animal model) 65% reduction in tumor volume! Tumor Volume (mm3) 30µl Frankincense essential oil
AKBA increases cancer drug effects Near doubling of the cancer cell (leukemia) killing power of the drug 5-FU when combined with AKBA Cytotoxicity (%)
AKBA combined with curcumin stops colon cancer cells Animal Model
conclusion Telephone: 1-877-668-4493 Access Code: 660 960 027
What to know about boswellia • 10% AKBA • Purified to <4 or 5% beta boswellic acid • Dosage: 500-1,000 mg daily Asthma COPD IBS Cancer Colitis
Thank you! Questions?
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