1 / 10

The Evaluation of Cardiometabolic Risk in the offsprings of the type 2 diabetic patients

The Evaluation of Cardiometabolic Risk in the offsprings of the type 2 diabetic patients. Ankara Eğitim ve Araştırma Hastanesi Endokrinoloji ve Metabolizma Hastalıkları Kliniği. Dr.Yavuz Selim Demir. Aim -----------------------------------------------------------

sydnee-case
Download Presentation

The Evaluation of Cardiometabolic Risk in the offsprings of the type 2 diabetic patients

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. The Evaluation of Cardiometabolic Risk in the offsprings of the type 2 diabetic patients Ankara Eğitim ve Araştırma Hastanesi Endokrinoloji ve Metabolizma Hastalıkları Kliniği Dr.Yavuz Selim Demir

  2. Aim ----------------------------------------------------------- To determine the incidence of cardiometabolic risk factors such as obesity , glucose intolerance , hypertension , hyperlipidemia ,elevated PAI-1 and CRP in the offsprings of type 2 diabetics.

  3. Methods • ------------------------------------------------------------------- • 40 subjects between ages 20 - 65 , without known cardiovascular disease which were offspring of a diabetic parent were included. • OGTT was performed on all subjects and classified according to • ADA critera . (IGT, IFG , DM , NGT) • Subjects with diagnosed cardiovascular disease and \ or glucose intolerance were excluded from the study. • Weight ,waist circumference ,body mass index (BMI) , fasting and postprandial glucose , insulin , lipid profile , systolic and diastolic blood pressure , PAI-1 and h-CRP levels were evaluated.

  4. * Compared to NGT p<0.05 ** Compared toNGT ve IFG p<0.05 *** Compared toNGT ve IGT p<0.05 **** Compared toIGT ve IFGp<0.05

  5. Discussion Glucose metabolism disorder (IFG+IGT+DM) was diagnosed in 67.5 % of the subjects with diabetic parent(s) PAI -1 levels were higher in IFG,IGT ve DM groups compared to NGT group Cardiometabolic risk increased in subjects with glucose tolerance from IFG <IGT<DM.

  6. JEAN-CLAUDE N. MBANYA et al. • 23% glucose metabolism disorder (DM,IGT) was diagnosed in • 69 offsprings of diabetic patients. • Diabetes Care 23:1761–1765, 2000 • GURLEK A et al. • Normal glucose tolerant offsprings of type 2 diabetic subjects • have elevated PAI-1 activity/The elevated PAI-1 activity has no association • with plasma insulin concentration. • Diabetes Care.2000 Jul 23 1035-7 • .

  7. CONCLUSION • Offsprings of diabetic patients are also at risk for cardiometabolic risk. • As soon as the parent is diagnosed offsprings of type 2 diabetic patients should be followed and evaluated forglucose intolerance and cardiometabolic risk

More Related