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Chapter 10: Non-narcotic Anti-Inflammatory Analgesics

Chapter 10: Non-narcotic Anti-Inflammatory Analgesics. Presented by: Katie and Steffani. NSAID:. Nonsteroidal anti-inflammatory drug It is a peripherally acting, anti-inflammatory analgesics. Various Actions of Asprin:. Anti-inflammatory Antipyretic Analgesic Anticoagulant.

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Chapter 10: Non-narcotic Anti-Inflammatory Analgesics

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  1. Chapter 10: Non-narcoticAnti-Inflammatory Analgesics Presented by: Katie and Steffani

  2. NSAID: • Nonsteroidal anti-inflammatory drug • It is a peripherally acting, anti-inflammatory analgesics.

  3. Various Actions of Asprin: • Anti-inflammatory • Antipyretic • Analgesic • Anticoagulant

  4. Therapeutic Uses and Clinical Problems: • Reducing Fever • Reducing Pain • Reducing inflammation • Reducing Clotting • Anticoagulation action might prevent problems if a person needs to clot and they are chemically restricted by the aspirin.

  5. COX Inhibitor: • A chemical which inhibits the enzyme cyclooxygenase which converts a precursor substance to prostaglandins that cause inflammation.

  6. # ONE & # TWO: • COX – 1 functions primarily to mediate the production of prostaglandins that protect and regulate all functions in the GI tract and regulated blood platelets to initiate clotting. • COX – 2 produce prostaglandins that mediate pain and inflammation.

  7. Good  and Bad  of the Anticoagulant Action of Aspirin: • Good - reduces hemostasis so is indicated in the treatment of Coronary Artery Disease (CAD) and is used to reduce risk of Cerebral Vascular Accident (CVA: Stroke). • Bad - causes symptoms ranging from dyspepsia to GI bleeds

  8. Theoretical advantages of COX-2 inhibitors over NSAIDs (non-selective COX-inhibitors) are decreased GI toxicity and platelet blockage.

  9. Correlation between COX enzyme and tumorigenesis: COX enzyme has a role in exciting tumor cell growth because it is over expressed in malignant adenomatous polyps and colon cancer. Benefits of COX inhibitors: have preliminarily shown efficacy in treating skin and colon cancer.

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