1 / 12

Beneficiary 1 : Istituto di Ricerche Farmacologiche Mario Negri

Beneficiary 1 : Istituto di Ricerche Farmacologiche Mario Negri Beneficiary 2 : Istituto Superiore di Sanità Beneficiary 3 : Federazione Nazionale dell’Industria Chimica Beneficiary 4 : Politecnico di Milano, Dipartimento di Elettronica e Informazione

tadhg
Download Presentation

Beneficiary 1 : Istituto di Ricerche Farmacologiche Mario Negri

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Beneficiary 1 : Istituto di Ricerche Farmacologiche Mario Negri Beneficiary 2 : Istituto Superiore di Sanità Beneficiary 3 : Federazione Nazionale dell’Industria Chimica Beneficiary 4 : Politecnico di Milano, Dipartimento di Elettronica e Informazione Beneficiary 5 :KnowledgeMiner Software Frank Lemke

  2. Promotion of non testingmethods (NTM) fortheiruse in the REACH contextlinkingscientists, regulators and industries toevaluate and validateexisting NTM fortheirapplicationaccordingto REACH needs

  3. REACHpromotesInnovation(Article 1) REACH &INNOVATION AllInfo should be used QSAR ismentioned

  4. QSAR (Q)SAR = (Quantitative) Structure-Activity Relationship IN SILICO = f ( )

  5. Survey of current methods for the compliance to the REACH legislation Identification of the criteria for the non-testing methods for the REACH legislation Identification of suitable experimental databases/data sets for the ecotoxicological, toxicological and environmental endpoints for REACH List of (Q)SAR models for the ecotoxicological, toxicological and environmental endpoints for REACH, and their review Validation of non-testing methods (incl. read-across) Identification of boundaries for best use of models (applicability domain) and of the assessment factors

  6. Architecture for integration of different non-testing methods for best performances and coverage of applicability Communication and dissemination initiatives Web portal Project management Monitoring Audit After-LIFE Communication plan

  7. LIST OF ITALIAN LABORATORIES WHICH CAN PRODUCE THE EXPERIMENTAL RESULTS REQUESTED FOR REACH Endpointsproducedfor REACH byLaboratories

  8. Carcinogenicity: Results • Global Predictions on the 1544 compounds (CPDB+Leadscope) of the seven programs examined

  9. BCF – Best Models based on R2 and Accuracy Ordered by R2

  10. CONCLUSIONS IN SELECTED CASES NON-TESTING METHODS CAN BE USED: BEST MODELS: mutagenicity, BCF; CRITICAL MODELS: daphnia, carcinogenicity; Important to consider the applicability domain; Important the correct evaluation of the results (expert); USE of more than one model preferable.

More Related