Cervical Spine Pathologies and Treatments

1. Cervical Spine Pathologiesand Treatments Jorge D. Flechas MD, MPH, H(MD) 80 Doctors Dr Ste 3, Hendersonville, NC 28792 (828-684-3233)

4. Anatomy Hemispheres Functions Compares intended movement with what is actually happening Smooth, coordinated movements Posture/balance Cerebellum

5. Anatomy Medulla oblongata Pons Midbrain Functions Medulla Relays motor and sensory information Regulates heartbeat, breathing and blood vessel dilation Pons Control breathing Brain Stem

9. Cerebral Spinal Fluid • Formed in the choroid plexus • Reabsorbed into saggittal sinus by arachnoid villi • Protects brain against concussive trauma • removes waste products

10. Foramen of Monro

11. I: Olfactory II: Optic III: Oculomotor IV: Trochlear V: Trigeminal VI: Abducens VII: Facial VIII:Vestibulocochlear Acoustic IX: Glossopharyngeal X: Vagus XI: Accessory XII: Hypoglossal Cranial Nerves http://www.gwc.maricopa.edu/class/bio201/cn/cranial.htm

12. CN V: TRIGEMINAL • Cranial nerve V • Function: sensory nerve of the face • Clinical test for injury: • corneal reflex; sense of touch, pain, and temperature; clench teeth; move mandible side to side • Effects of damage: • loss of sensation and impaired chewing

13. Cranial Nerve VI Function: Eye movements Clinical test: lateral eye movement Effects of damage: inability to rotate eye laterally; at rest – eye rotates medially because of action of antagonistic muscles Cranial Nerve VII Function: facial expression; sense of taste Clinical test: motor functions – close eyes, smile, whistle, frown, raise eyebrows; taste Effects of damage: inability to control facial muscles; distorted sense of taste CN VI: ABDUCENS AND CN VII: FACIAL

14. CN VIII: VESTIBULOCOCHLEAR • Cranial Nerve VIII • Function: hearing and equilibrium • Clinical tests: test hearing, balance, and ability to walk a straight line • Effects of damage: deafness, dizziness, nausea, loss of balance, and nystagmus

15. Cranial Nerve IX Function: swallowing, salivation, gagging; touch, pressure, taste, and pain sensations from tongue, pharynx, and outer ear Clinical tests: gag reflex, swallowing, and coughing Effects of damage: difficulty swallowing Cranial Nerve X Function: swallowing; taste; speech; respiratory, CV, and GI regulation; sensations of hunger, fullness, and intestinal discomfort Clinical tests: test with cranial nerve IX Effects of damage: hoarseness or loss of voice; impaired swallowing and GI motility CN IX: GLOSSOPHARANGEAL AND CN X: VAGUS

16. Cranial Nerve XI Function: swallowing; head, neck, and shoulder movements Clinical tests: rotate head and shrug shoulders against resistance Effects of damage: impaired movement of head, neck, and shoulders; paralysis of sternocleidomastoid Cranial Nerve XII Function: tongue movements of speech, food manipulation, and swallowing Clinical test: tongue function Effects of damage: difficulty in speech and swallowing; atrophy of tongue; inability to stick out (protrude) tongue CN XI: ACCESSORY AND CN XII: HYPOGLOSSAL

17. Brain and Brain Stem

18. Sympathic Nervous System

19. Base of Skull

20. Treatment of Foramen Magnum

21. Degenerative Disease of the Spine • Degenerative processes of aging occur at different rates, locations, and modalities, based on the unique attributes of individuals (factors known to influence degenerative diseases of the spine include lifestyle, work patterns, diet, and even genetics) Normal Degenerative

22. Cervical Spondylosis • Cervical spondylosis is a general term encompassing a number of degenerative conditions • Degenerative disc disease (DDD) • Spinal stenosis • With or without degenerative facet joints • With or without the formation of osteophytes • With or without a herniated disc • One single component as a diagnosis is rare

23. Degenerative Disc Disease • The process is thought to begin in the annulus fibrosis with changes to the structure and chemistry of the concentric layers • Over time, these layers suffer a loss of water content and proteoglycan, which changes the disc’s mechanical properties, making it less resilient to stress and strain Normal Pathology

24. Degenerative Disc Disease • The process is thought to begin in the annulus fibrosis with changes to the structure and chemistry of the concentric layers • Over time, these layers suffer a loss of water content and proteoglycan, which changes the disc’s mechanical properties, making it less resilient to stress and strain Degenerated Pathology

25. Degenerative Disease: Facet Joints • Changes in disc structure and function can lead to changes in the articular facets, especially hypertrophy (overgrowth), resulting from the redirection of compressive loads from the anterior and middle columns to the posterior elements

26. Degenerative Disease: Osteophytes • There also may be hypertrophy of the vertebral bodies adjacent to the degenerating disc; these bony overgrowths are known as osteophytes (or bone spurs)

27. Herniated Nucleus Pulposus • The progressive degeneration of a disc, or traumatic event, can lead to a failure of the annulus to adequately contain the nucleus pulposus • This is known as herniated nucleus pulposus (HNP) or a herniated disc

28. Herniated Nucleus Pulposus • Varying degrees • Disc bulge • Mild symptoms • Usually go away with nonoperative treatment • Rarely an indication for surgery • Extrusion (herniation) • Moderate/severe symptoms • Nonoperative treatment

29. Herniated Nucleus Pulposus • Symptoms • Neck pain • Shoulder pain • Arm pain • Dysthesias • Anesthesias • May resemble carpel • tunnel syndrome, rotator • cuff problems, or gout

30. Herniated Nucleus Pulposus • Diagnosis • Magnetic resonance imaging (MRI)/patient examination • Motor deficit is an indication of spinal cord compression and requires urgent surgery • Not all HNPs are symptomatic

31. Spinal Stenosis • Grouped as “spinal stenosis” • Central stenosis • Narrowing of the central part of the spinal canal • Foraminal stenosis • Narrowing of the foramen resulting in pressure on the exiting nerve root

32. Spinal Stenosis

33. Stenotic Normal

34. T2- and T1-weighted sagittals at midspine showing spinal canal stenosis from C4/C5/C6 level

35. Spinal Stenosis • Symptoms • Neck pain • Pain, dysthesias, anesthesias in arms and hands • Bilateral

36. Spinal Stenosis • Diagnosis • MRI/computerized tomography (CT)scan/patient examination • Failure of nonoperative care —minimum 6 months • Rest, nonsteroidal anti-inflammatory (NSAID) medication, physical therapy, epidural steroid injections

37. Cervical Spondylotic Myelopathy • The most common type of spinal cord dysfunction in patients older than 55 years • Onset is usually insidious, with long periods of fixed disability and episodic worsening • The first sign is commonly gait spasticity, followed by upper-extremity numbness and loss of fine motor control in the hands

38. Cervical Spondylotic Myelopathy • Unlike most degenerative conditions of the back and neck, conservative treatment is not indicated • Performing surgery relatively early (within 1 year of symptom onset) is associated with a substantial improvement in neurologic prognosis • Delay in surgical treatment can result in permanent impairment

39. Cervical Spondylotic Myelopathy • Symptoms • Pain in the neck, subscapular area, or shoulder • Anesthesias or paresthesias in the upper extremities • Sensory changes in the lower extremities • Motor weakness in the upper or lower extremities • Gait difficulties • “Upper motor neuron” findings; “lower motor neuron” findings

40. Cervical Spondylosis Without Myelopathy • Surgical care • For radicular/neurologic symptoms • Not for axial neck pain • Dependent on the anatomy and the lordosis of the affected segments, and surgeon preference • Anterior cervical discectomy and fusion • Anterior cervical corpectomy (multiple levels) • In some cases, adjunct posterior-instrumented fusion

41. Cervical Spondylotic Myelopathy • Surgical care • Posterior cervical fusion—instrumented • Dependent upon the anatomy and the lordosis of the affected segments, and surgeon preference • Posterior cervical fusion • Laminoplasty • May involve an adjunct anterior fusion procedure to address spondylosis

42. Neurological Abnl. In Fibromyalgia (FM) • Nystagmus: 64% Usually fine or rotatory, more prominent in extension • Convergence abnormal : 43% Often asymmetric left eye usually worse • Horner’s syndrome: 31% • Absent corneal reflex: 37% Uni- or bilateral • Other V abnormality:69% Often intraoral

43. Neurological Abnl. In FM • VII abnormality 20% Most apparent with testing of orbicularis oculi • VIII abnormality 46% • IX-X abnormality 60% Usually included uni- or bilaterally absent gag reflex

44. Neurological Abnl. In FM • Upper extremities 86% Usually multiple groups • Lower extremities 94% Most often iliopsoas, usually bilateral

45. Sensory function: • 88% Multiple modalities were usually abnormal

46. Deep tendon reflexes: • Normal: 15% • Hyper-reflexia 52% • Hypo-reflexia 19% • Both Hyper- and Hypo- 14%

47. Pathological reflexes: • Babinski’s response • Normal 40% • Equivocal • Unilateral 14% • Bilateral 6% • Present • Unilateral 15% • Bilateral 25%

48. Brainstem Summary • The brainstem not only is adequate explanation for symptoms such as dysphagia, dysphonia, difficulty with balance and other, but it also harbors the centers for cardiovascular control, gastrointestinal control, respirations and the reticular activating system . The latter is particularly important with regard to sleep, arousal, attention and the subsequent incorporation of memory. The lower medulla also is the source of origin for descending nociceptive control fibers, which originate in the nucleus raphe magnus and paragigantocellularis .

49. FM and Neurological Deficit • Fibromyalgia is not an explanation for neurological deficit, no matter how subtle it may be. Neurological abnormalities should invoke a search for treatable lesions: that search should focus on the upper spinal cord and brainstem based upon the observations presented here.

50. Conclusions: • In patients with the previous diagnosis of Fibromyalgia who also had positive tilt table examinations for NMH/POTS, physical examination abnormalities were common. • These abnormalities center about the lower • brainstem and upper spinal cord. • Fibromyalgia (and related syndromes) is not an adequate explanation for neurological abnormality.