1 / 9

Public Cord Blood Banking in the United Kingdom

Public Cord Blood Banking in the United Kingdom. Derwood Pamphilon Consultant Haematologist Medical Director, NHS Cord Blood Bank NHS Blood and Transplant. The NHS Cord Blood Bank. Started clinical banking in February 1996

tait
Download Presentation

Public Cord Blood Banking in the United Kingdom

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Public Cord Blood Banking in the United Kingdom Derwood Pamphilon Consultant Haematologist Medical Director, NHS Cord Blood Bank NHS Blood and Transplant

  2. The NHS Cord Blood Bank Started clinical banking in February 1996 Accredited by NetCord-FACT* and licensed by the Human Tissue Authority Present aim To bank 20,000 altruistic (unrelated) donations To bank units from ethnic minority groups Available for search in the British Bone Marrow Donor Registry (BBMR) and NetCord First unrelated transplant Feb 1998 in a 5 year old child with advanced acute leukaemia who remains well *Foundation for Accreditation of Cell Therapy

  3. Advantages of Cord Blood Banking • Readily available: 600,000 live births each year in the UK • Short interval from search to transplant • Donations from ethnic minorities • Low risk of transmission of latent viruses • No attrition once bank established • T cells are naïve – less Graft-versus-Host Disease (GvHD)

  4. Principal Elements of Cord Blood Banking Promotion Donor mother recruitment Donor selection Maternal blood samples Cord blood collection Transport Lab management Quality system Testing HLA typing Data management Registration Traceability Request Process Search Cryopreservation Selection Storage Reservation Release & Issue Archive samples Follow up

  5. What Have We Achieved? Banking • 13,500 units banked • 4th largest single public bank in the world • 2nd highest % of rare tissue types Issued • 260 units to 22 countries • 34% units issued were from donors from ethnic minorities • 30% for double cord transplants Survival • 2 year survival - 69% in high risk patients receiving HLA (Human Leucocyte Antigen or ‘Tissue Type’) matched or grafts Geographical Distribution of NHS Cord Blood Bank Units Issued (n=173)

  6. Public Donation Now and in the Future • Our emphasis is on providing stem cells for therapy where clinicians agree that benefit is likely • Possible increase in collection sites in areas with high ethnic diversity • Potential exists for collaboration with the private sector (Technopolis Report) • Public donation remains an altruistic choice

  7. Should the NHS take steps to increase public awareness? • Develop a National Policy on Cord Blood with a high-level advisory committee* • Provide all hospitals with a level playing field • Ensure that all hospitals make clear and accurate information on cord blood banking available • Develop clear guidelines for private banks regarding the information they supply *Technopolis Report, September 2008

  8. The Next 10 Years of Cord Blood • Possible further expansion in the UK to 50,000* • Double cord blood transplants • Cord Blood + half-matched adult stem cells • Cord blood for regenerative medicine and tissue repair Querol et al, Hematologica, 2009

  9. Acknowledgements Colin Brown Hazel Cockburn Marcela Contreras Sue Davey Jon Ellis Jesmina James Delordson Kallon Cristina Navarrete Fiona Regan John Smythe Suzanne Watt www.cord.blood.co.uk

More Related