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Regional Immunity in Melanoma Immunosuppressive changes precede metastasis

Regional Immunity in Melanoma Immunosuppressive changes precede metastasis. Aaron Mansfield, MD. Outrun the Sun Melanoma Research and Education Forum October 6, 2011. Hypothesis. Melanoma suppresses the immune system Suppression promotes metastasis. T cells.

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Regional Immunity in Melanoma Immunosuppressive changes precede metastasis

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  1. Regional Immunity in MelanomaImmunosuppressive changes precede metastasis Aaron Mansfield, MD Outrun the Sun Melanoma Research and Education Forum October 6, 2011

  2. Hypothesis • Melanoma suppresses the immune system • Suppression promotes metastasis

  3. T cells • T cells critical component of immune system • Cell-mediated immunity • Regulatory T cells • Th1: cytotoxicity • Th2: humoral response, inhibits Th1

  4. Markers • Regulatory T cells Foxp3 • Th1 cells T-bet • Th2 cells GATA3

  5. Lymph node

  6. Positively-stained area

  7. Lymph Nodes • Sentinel lymph nodes without melanoma • Sentinel lymph nodes with melanoma • Reactive lymph nodes • Dormant lymph nodes

  8. Regulatory T cells

  9. Th1 transcription factor

  10. Th2 transcription factor

  11. Conclusions • Lymph nodes are suppressed prior to spread of melanoma • Both Th1 and Th2 transcription factors are downregulated • Controls can significantly impact interpretation

  12. Questions • What drives immunosuppression? • Do these findings relate to survival or recurrent disease?

  13. Acknowledgements • Outrun the Sun • SvetomirMarkovic • Travis Grotz • Lori Erickson • ShernanHoltan • James Jakub • Jake Allred

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